Solutions for Contract Packaging and Filling Companies

Contract packaging companies provide many businesses with the resources they need to succeed. Being able to deliver high-quality products in reliable packaging that is as practical as it is cost-effective is one of the greatest advantages setting many pharmaceutical, cosmetics, and familiar businesses apart from their competition.

What makes LF of America among the top contract packaging companies in the USA is our commitment to each of our prospective clients. Using state-of-the-art contract packaging and filling equipment along with an exceptionally high standard of quality, our clients can trust that we handle every one of the products we handle with the same level of care we would if it were our own.

If you’re looking for contract packaging and filling companies that you can depend on for ongoing reliability, here’s how LF of America can help.

Contract Packaging Services

Our available contract packaging options extend far beyond the unique containers we manufacture. The diverse variety of innovative packaging options we carry enables clients to make the most of the products they provide. In addition, it helps businesses show their customers that they care just as much about the consumer’s use of the products as they do about the products themselves.

We manufacture different packaging options that include unit dose packaging, wand tubes, bottles with droppers, dual chamber bottles, enema containers, vaginal containers, and the specially designed Bellows Bottles. Each of these is available in different options to ensure they are suitable for the unique applications associated with every product they contain. We also provide custom packaging manufacturing services to further meet the more specialized needs of specific clients.

Contract Filling Services

Our in-house contract filling services are a cost-effective option for companies within the pharmaceutical, cosmetics, veterinary care, diagnostics, and familiar industries. We are capable of safely filling liquids in most liquid viscosities, including liquids, gels, creams, and even powders.

Moreover, as turnkey contract packaging partners, we are able to fulfill production demands from start to finish. Our turnkey services are from formulation to batching, packaging selection, and filling, all delivered by one convenient source. We even carry contract filling machines for sale that give our clients the chance to introduce their very own in-house filling solution.

End Your Search For Contract Packaging Companies

If you’re searching for contract packaging companies and are unsure which choice is the best option, we can help. LF of America is proud to be the US-based member of the Lameplast Group, a worldwide leader in contract packaging.

We perform all our contract packaging and filling services in-house and utilize an ISO-8 cleanroom to guarantee safety and quality control. Contact us to get a free quote for any of our contract packaging and filling services or to learn more about what makes us your perfect packaging partners call 800-829-5741.

ST-120S Industrial Cap Torque Tester

The ST-120S features a servo drive control, infinite chuck rotation, quick-change tooling, a color touchscreen interface, and faster cycle times.

The corrosion-resistant stainless steel head enclosure and anodized aluminum frame construction make the ST-120S ideally suited for the most demanding applications, such as testing closure torque at Carbonated Soda Drink (CSD), juice, bleach bottling operations as well as cleanroom environments.

The unit is equipped with anti-bridging, anti-tie down anti-repeat dual actuation safety start switches, but for maximum operator safety, the ST-120S can be also equipped with a full machine guard.

Features

  • Real-time, automatic display
  • NIST traceable calibration procedure
  • Strain gauge transducer technology
  • Automatic container clamping and closure gripping
  • Adjustable torque application speed
  • Counterbalance system for height adjustment
  • Infinite rotation (SERVO)
  • Encoder to measure the angular degree of rotation
  • Heavy-duty components

Testing Capabilities

  • Applied Torque: The ST-120 can be used as a benchtop capper, tightening the cap to a customer-defined setpoint.
  • Release Torque: The ST-120 is designed to accurately measure the release (thread break) torque of a cap.
  • Peak/Transient Torque: The standard ST-120 can measure and display the Applied or Release Peak in a torque testing cycle, however with optional hardware upgrades it is also possible to measure certain torque transients such as the engagement torque of a CR closure system or the peak of the bridge break torque of a Tamper Evident Band.
  • Container/Closure Fatigue: By allowing the ST-120 to apply and release the cap a number of times, it is possible to evaluate the effect of fatigue on the torque retention and seal quality of the closure and seal.
  • Release and Re-apply Torque: When packaging expensive products it is often required to return the tested container to the packaging line. By automatically re-applying the torque to the operator defined setpoint it is possible to save the product.
  • Topload Force (optional): This feature allows the monitoring and control of topload force. When testing child resistant caps or other closures requiring topload adjustment this feature allows the evaluation of topload force in the function of rotation and torque.

Contact Life Scientific, Inc. for more information on this equipment.

How does Vetromeccanica’s Vacuum Conveying Work?

Vacuum Conveying is the process of moving bulk dry materials, such as powders, from place to place within a factory using suction. The material is transferred in a network of tubing from the pickup point or source to the customers’ process. Most Vacuum Conveying System transfer product based on a timed interval to the vacuum receiver. At the end of the timed sequence, the discharge valve can open and the material conveyed can discharge into the process. 

There are two types of vacuum conveying. Dilute phase conveying and Dense phase conveying. 

  • Dilute Phase Conveying the material is entrained in the air stream and the is an almost equal part of air and product. This method is excellent for conveying almost any type of powder-like sugar or flour. 
  • Dense Phase Vacuum Conveying the material is transferred in slugs within the convey tubing. The material moves slower then dilute phase conveying and is an excellent choice for a friable product or a blend of powders. 

Vetrommecanica’s conveying systems differ from others because they increase the real plant efficiency. They are a major player in more than 70 Countries thanks to the care and attentiveness to details, capability to offer a 360° all-rounded service, and to their extremely skilled customer-care department.

Learn more about the conveyance solutions we are currently offering by giving us a call at 800-829-5741

Onion Skin Ampoule Filling and Sealing

A manufacturer of drug and explosive detection equipment for law enforcement, hazmat teams and educational systems.

Cozzoli were approached about a need for filling onion skin style ampoules. These ampoules would be part of a mobile detection system, where after swabbing a potentially contaminated area, the swab is inserted into the pouch and the ampoules are crushed. The chemical inside of the ampoule mixes with the swab and will detect if any drug or explosive residue is present.

This application would require the ampoule to be filled with a small and very precise amount of liquid, then flame sealed.

This was a perfect application for our FPS series ampoule filling and sealing MonoBlock. The application required the filling of 6.70mm x 60mm onion skin tubes with .10 mL -.40 mL of liquid. This would have to be done at a production rate of 45 -50 ampoules per minute. Due to these requirements, the FPS1-OS-SS was chosen for the job.

Our FPS series monoblock fills and seals a variety of ampoule shapes and sizes, at speeds of 15-120 ampoules per minute and a fill accuracy of +/- .5%.

With the fill volume requirements being so small, a peristaltic pump was added in order to feed the liquid into the machine. A peristaltic pump is typically used for very precise filling applications, as well as applications where the liquid is clean/sterile and cannot come into contact with any exposed pump components.

For more information on how we can help with your ampoule filling applications, contact us at 800-829-5741

Fedegari: Advancing aseptic processing

While pharma has made tremendous strides in aseptic processing, the industry still struggles with contamination issues — indicating there is more work to be done. Like all segments of the pharma industry, aseptic manufacturing continues to be transformed by disruptive technologies. With the goals of maintaining compliance, lowering costs, and streamlining processes always at the top of mind for drugmakers, industry vendors are innovating solutions that incorporate the latest trends and capabilities.

“Firms are striving to reduce costs and improve process flexibility, while fundamentally eliminating some of the potential contamination challenges,” says Ben Wylie, senior product manager at ChargePoint Technology.

Pharma may be close to mastering aseptic manufacturing, but innovative tweaks and updates to equipment and operations are helping improve the process even more.

Robots have been a game-changer in the packaging department of facilities, and are now transforming the filling process as well.

“Robotics are progressively more available in aseptic processing due to the flexibility they allow — saving time for the operator who would otherwise need to change parts to fill very different kind of vials, syringes and cartridges,” says Federico Fumagalli, chief commercial officer at Steriline. “With robotics machines, they just have to change a single parameter on the robot to change the whole production process.”

Steriline’s Robotic Vial Filling Machine was designed specifically to address the industry’s growing need for flexibility. According to the company, the machine can be equipped with one or two Stäubli vaporized H2O2 resistant anthropomorphic robotic arms (depending on output requirements), which transport the vials within the machine.

Although Fumagalli says there are pros and cons to using robotics, a cost-benefit analysis favors robots because they can reduce downtime, prevent product loss and decrease waste.

“In case a vial is not correctly stoppered, the robot can repeat the stoppering cycle to complete the process,” he says. “On a traditional machine the vial would be rejected — the content discarded — losing a potential earning, and the company would have to dispose of the waste, incurring further costs. Using a robotic system, the vial could go backwards and be stoppered during a second cycle, without any waste.”

Fedegari Technologies has also been developing ways to combo advanced solutions, including robotics, into one piece of machinery.

“The manufacturing processes of the future will streamline new technologies like robotics, artificial intelligence and IoT, into an increasingly closed and connected production process,” says Jeffrey Siterlet, managing director of Fedegari Technologies in North America. “By linking components, isolating the process and centralizing control, tomorrow’s manufacturing process will facilitate efficiency, safety and compliance while eliminating risk.”

The company’s new washer sterilizer, for example, offers sterilization, washing and bio-decontamination in one solution. The gloveless sealed isolator hosts a GMP robotic arm that can be adapted for different batch sizes and simplifies cleaning requirements needed to enter a controlled-contamination environment.

Single-use solutions continue to play a dominating role in pharma manufacturing innovations and provide a wide variety of benefits.

“As single-use and disposable products become more widely utilized, the manufacturing process becomes more efficient through quicker changeovers and set-up times and drug manufacturers can react more rapidly to product and customer demands,” says Wylie.

ChargePoint recently added two products to its single-use portfolio including the ChargePoint Single Use Passive (SUP) and ChargeBag PE-S with new HiPure ULP7 PE film. Together, the two products are intended to form a high performance, single-use package for the contained and sterile transfer of powders between manufacturing process steps or even facilities.

The company says that the ChargePoint SUP is a disposable version of the passive mating half of the ChargePoint SBV (Split Butterfly Valve) technology, which forms a complete hybrid system to ensure users can take advantage of the benefits of disposable technology.

“Technologies such as SBVs are increasingly replacing traditional open transfer techniques, enabling contained and efficient materials transfers,” Wylie says.

Importantly, single-use innovations are also happening for the final stage of the manufacturing process: Transport.

“As the trend of biologics being manufactured in one location and going through the final fill process in another grows, the need for materials that can withstand manipulation at temperatures down to -86 degrees C continues to accelerate,” says Alex Kakad, product marketing manager for AdvantaPure.

AdvantaSil Ultra Low Temperature Silicone Tubing is designed to remain flexible (as opposed to cracking and leaking fluids) at temperatures as low as -112°C. According to the company, its tubing and molded closure assemblies have glass transition temperatures below -100 °C, allowing for a comfortable safety factor for these demanding applications. This, AdvantaPure says, makes the tubing an optimal choice for applications related to bulk drug storage and transport.

From the first stages of aseptic processing until products exit the factory doors, technology trends are continuing to transform sterile pharma operations.

For further information on products that incorporate this technology please contact our corporate offices and/or sales representatives.

The Newman S250 Labelling Machine

The Newman S250 Labelling Machine is a fully automatic, versatile self adhesive labelling system for the application of paper and clear labels to cylindrical, rectangular or square containers in glass, plastic, metal or composite materials.

The S250 has been specifically designed to meet the requirements of the international pharmaceutical industry and its regulatory bodies, including the FDA, but is equally suited to other industries where flexibility, high speed, accuracy and reliability are pre-requisites. 

A variable speed roller at the infeed spaces the containers entering the machine. Each individual container is detected at the labelling point as it passes a sensor, at which point the label feed is activated. The leading edge of the label is driven off the backing web at a linear speed that matches the container speed; this ensures smooth, accurate placement on the container surface. The container, gripped between an applicator drum and presser pad, is controlled as the label is pressed firmly in place, ensuring high registration accuracy.

Features

  • Compact cGMP Design
  • ‘Auto-teach’ label length facility
  • Digital scales for rapid container changeover
  • Positive accept security system
  • Fully validated security system with Critical Device Checking
  • Minimal change parts
  • High performance stepper motor for label web drive
  • In Process Control – system verification without production stoppages
  • Accurate label placement
  • Stainless steel 304 finish
  • Siemens orAllen Bradley PLC control system
  • Hot foil coding unit
  • Validation documentation and implementation package
  • Auto-reject system for both incorrect label data and missing label detection with reject verification
  • Touch screen HMI with run mode and set up mode (key switch access) facility
  • Counter package with full count reconciliation
  • Secondary presser unit – labels over 110mm or square / rectangular container applications
  • End of web detection
  • Container feed by gating rollers or optional feed scroll

Options

  • Belt applicator system for higher speed option, up to 300 cpm
  • Printout facility
  • Continuous label supply via the Easisplice 470 unit
  • Queue switch control
  • Vision Systems for OCV / OCR / barcode
  • Rotary infeed & outfeed tables
  • Thermal transfer, laser and inkjet printing
  • Left and Right hand option available

Contact us for more information on product specification and pricing!

Ophthalmic Contract Filling and Packaging

Ophthalmic contract filling has long been important in producing and packaging medications that treat ophthalmic diseases and eye irritations. Although most ophthalmic medication is easy to produce, the packaging for this medication has been traditionally tricky. These issues have prompted pharmaceutical companies to find experts in contract packaging and filling to solve these challenges. 

The contract filling and packaging industry have developed new innovations designed to address previous packaging concerns. This led to major breakthroughs including unit-dose packaging. By using single use pharmaceutical packaging for eye drops, companies and patients have begun to enjoy a number of advantages. Pharmaceuticals companies that adopt this innovation continue to report on the success of unit dose packaging

The article below will detail how ophthalmic contract filling can greatly benefit pharmaceutical companies compared to traditional eye product packaging. If you have any more questions or would like to learn more about our turnkey contract filling services, be sure to contact LF of America today to speak with a friendly and knowledgeable team member. 

Characteristics Of Traditional Ophthalmic Packaging

In the past, eye medication packaging was centered around a bottle with a dispensing tip and a tamper-resistant design. This form of packaging was known as bottles with droppers and became widespread due in large part to their durability and cost-effectiveness.

Despite their popularity and widespread use, they characteristically have a number of limitations that have been a challenge for pharmaceutical companies with ophthalmic medications. 

The major challenge with ophthalmic contract packaging has always been dosing and storage. Users have in the past reported difficulty with applying exact doses equally to both eyes. The materials used in the packaging would also interact with the medication inside.

This chemical interaction could possibly change the medication and cause a burning sensation for users. These challenges have been an issue until the recent advent of new ophthalmic packaging options

New Innovations in Contract Ophthalmic Filling

LF of America is a contract filling and packaging company that continues to innovate and provide advanced packaging and filling solutions. Our experienced packaging division has designed ophthalmic contract filling solutions that address the challenges and limitations unique to ophthalmic medications.

Our patented multi-layer technology and one-hundred percent preservative-free formula revolutionizes ophthalmic medication packaging by making it easier to store and much more comfortable to use for patients. When combined with our state-of-the-art automatic filling machines, manufacturers and users alike benefit in convenience, safety, and efficiency.

Some of the advantages provided by our ophthalmic packaging and filling solutions include:

  • Equal API Delivery in Both Eyes
  • 100% Preservative Free Formula (no user reported burning sensation when used)
  • Unit-Dose Vial Designed In Two Pieces with A Sterile Orifice for Precise Dosing
  • Injection Molding Technology that Increases Safety and Flexibility

We are certain that your company and customers will see and feel the difference when you adopt our ophthalmic contract filling solutions. Contact LF of America today to learn more. 

SC50T Screw Cap/Aluminum Sealing Machine

The Cozzoli Screw Capper Model SC50T will cap sizes up to 95mm in diameter. The adjustable torque slip-clutch configuration rotates, giving uniformly tightened caps and preventing cap damage with gentle cap handling.

Configured as an aluminum Sealing machine, the SC50T features a selective two-speed drive to a rotating and reciprocating spindle, with a maximum up-down stroke of 2” or 50.8mm.

The Aluminum Sealer provides uniform roller-sealing of container crimp caps up to 43mm in diameter. In either configuration the SC50T is ideal for clean room lab use or small production facility.

An automatic version of this machine can be mounted on a fully integrated Cozzoli packaging line.

Screw cap configuration: With the cap in position, the operator places the container against a “V” plate. The reciprocating spindles then automatically descends to screw on the cap. Torqueing time can be adjusted from .15 to 10 seconds, thereby accommodating most capping speeds.

Aluminum Seal Configuration: With the cap in position, the operator places the container against a “V” plate. The crimping head that consists of 3 blades and 3 rollers then automatically descends to seal the cap; Crimping time can also be adjusted from .15 seconds to 10 seconds.

For pricing and more details call our corporate office at 800-829-5741.

Fedegari Integrated Systems

Fedegari has developed fully integrated robotized solutions for different customers world-wide helping them to achieve the best performances and increasing cost-effectiveness.

Fedegari, once known for its sterilizers, has turned today into a one-stop industrial group that delivers highly customized solutions where the bio/pharmaceutical industry is producing sterile drugs.

During the last years, Fedegari has developed fully integrated robotized solutions for different customers world-wide helping them to achieve the best performances and increasing cost-effectiveness.

Hereunder you can find a couple of examples of turn-key integrated systems that we have engineered and developed, together with our customers, to reach the highest levels of cost-effectiveness in their pharmaceutical plants.

No matter the form of the drug, the packaging, or the process, there is always a smarter, more cost-effective alternative in manufacturing.

Contact our Representatives for further information: 800-829-5741

The Improvements in Ophthalmic Packaging

There are a number of ophthalmic diseases and eye irritations that require eye care medication to treat properly. Fortunately, the vast majority of ophthalmic medication is derived from a fairly simple solution. However, many ophthalmic packaging options have limitations and can even require irritating additives to be used in the formula.

In order to resolve the limitations of traditional ophthalmic packaging, many pharmaceutical companies are looking to contract packaging and filling experts for help. One of the more recent innovative advancements in eye drop packaging is through unit-dose packaging. Incorporating single use packaging for eye dropsprovides a number of useful advantages for the companies and users alike.

The following article will highlight the different ways that unit dose packaging can improve the storage and use of ophthalmic medication. If you’re interested in discussing eye medication packaging options with the premier contract packaging and filling company, contact LF of America for assistance.

The typical eye medication packaging is comprised of a bottle, dispensing tip, and tamper-resistant features. Standard bottles with droppers have been widely used for decades thanks to their affordability and durability. Although these standard eye medication containers are useful, they still have a few significant disadvantages.

Traditionally, liquid ophthalmic drug products come in multi-dose containers that are designed to protect the quality of the product, aid in dosing, minimize contamination concerns, and maintain overall sterility. The majority of ophthalmic products in multi-dose containers are intended to be used within a month after opening.

The primary concerns with traditional eye medication packaging are associated with dosing and storage. First, it can be difficult for users to apply a precise dose of the medication equally in both eyes. Second, because of the chemical interactions between the solution and the materials used in the container, preservatives are added that produce a burning sensation once the product is used.

In order to combat these disadvantages, LF of America has designed a more innovative ophthalmic packaging option that overcomes these problems. Using patented multi-layer technology and a 100% preservative-free formula, our unit dose packaging for eye drops makes administration easier and more comfortable. In addition, the single dose container permits users to easily administer the same precise dose in both eyes.

The benefits of our unit dose ophthalmic packaging over traditional eye drop containers include:

  • 100% Preservative Free Formula (no burning sensation caused by irritating additives)
  • Equal API Delivery in Each Eye
  • Two Piece Unit-Dose Vial with Clean Orifice for Calibrated Drops
  • More Comfortable Administration (no plastic flashes on opening)
  • Injection Molding Technology (increased safety and flexibility)

To learn more about our innovative eye medication packaging options, please contact our representatives.

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