Filling Methods by Cozzoli machines

For almost a century, Cozzoli Machine Company has provided technologically advanced machinery for the packaging industry. Till today Cozzoli has developed a variety of filling methods to meet your production goals.

Cozzoli offers inline or rotary filling with piston, peristaltic pump, diaphragm pump or time pressure technology. Choose continuous or intermittent motion, stand alone or monoblock configuration. Every Cozzoli filler provides unmatched ease of container handling and change-over. Provided below are the different Filling Methods that can be carried out with Cozzoli filling machines.

 

Fill – to – Level

Fill-to-Level fillers are especially suited for thin and foamy products, like cleaning solutions for example. These fillers compensate for variations in container volume while retaining cosmetic fill accuracy. All of this fillers operate on the principles of gravity, pressure and vacuum.

 

Time Pressure

Time Pressure filling is accomplished by controlling the flow of the product through the tubing. By design, the product stays in the manifold that feeds the tubes. A computer calculates the product flow time needed based upon manifold pressure, nozzle size and target fill volume.

 

Piston Filling

The Piston fillers can have industrial and aseptic applications. Piston fillers are ideally suited for filling a diverse range of products. These fillers are ruggedly designed yet precisely built for long trouble free operation. The piston product viscosity range can be from 1 to 100K centipoises and with slight customization even above that.

 

Peristaltic Pump

Peristaltic pump is a system where nothing but the tube touches the fluid eliminating the risk of the pump contaminating the fluid or the fluid contaminating the pump. The complete closure of the hose, which is squeezed between a shoe and the track gives the pump its positive displacement action preventing backflow and eliminating the need for check valves when not in operation.

 

Diaphragm Pump

Diaphragm Pump fillers are suited for corrosive chemicals, abrasive materials and delicate liquids. These are also used with blood, insulin and plasma filling systems. The Diaphragm pump is a completely enclosed system that eliminates air bubbles on small fills and features accurate repeated fills.

 

Rotary Time Pressure

Time pressure fillers are well suited for filling heavy viscosity products. The nozzle is open to the product for a specified amount of time to achieve proper fill volume. Proper fill is dependent on three critical areas: time of fill, pressure of the flow and filling speed.

 

Vacuum Powder

This totally enclosed system removes the possibility of product contamination. Fill volume of each piston can be independently adjusted during operation. Two to sixteen stations are available. Multiple dose fills are ade possible by simply setting the preferences on the micro-processor. This also provide a solution to product loss due to dusting issues that is virtually eliminated.

 

Call 800-829-5741 to inquire about pricing and to obtain additional info on the different filling and pumping systems developed by Cozzoli.

Introducing LRP-30, the new leak detection machine for monoblock aerosol cans

After the development of the LRP-20, a leak testing machine for aluminum tubes, the collaboration between Sprimag, a world leader in industrial painting equipment, and Bonfiglioli Engineering S.r.l., the Italian-based branch of Packaging Test and Inspection Specialist TASITEST, has led to another excellent result: the LRP-30, a leak testing machine for monobloc aerosol cans that can be integrated into any line system concept thanks to the line-oriented transfer in and out of the machine.

At first glance, the LRP-30 appears to be very similar to the necking machine normally located upstream of the testing process, but, as opposed to machines used to test welded steel cans, the test plate of the LRP-30, which is equipped with 30 testing heads, is supported above a large, horizontal shaft by a two bearing support of the shaft ends. When the system is in operation, the cans are transferred from the outfeed conveyor system of the necking machine to the infeed conveyor system, which has been deliberately kept short and compact. A vacuum transfer starwheel picks up the cans and transfers them directly to one of the 30 testing heads in order to detect holes up to a diameter of 0.04 mm with a high level of reliability. The number of testing heads results in significantly longer testing times and therefore much more precise test results compared to the machine concepts previously used for monobloc aluminum cans. After testing, the cans are transferred directly to the outfeed conveyor system of the testing machine and then on to the downstream packing machine, a palletizer or a robotic packaging solution.

The compact overall design, the optimized width of the machine and the line-oriented transfer in and out of the machine make the LRP-30 able to be integrated into any line system concept.

In addition to optimized floor space requirements, the LRP-30 provides an easy machine handling and a quick size part changing. The entire machine, together with the infeed and outfeed conveyor systems, is driven by a single servo drive, thus avoiding unnecessary complexity and susceptibility to failure.

Other benefits from this sophisticated machine concept are: the possibility to manage the can length adjustment for other can sizes via a single user command on the HMI; the identical system accessibility of the machine corresponding to the upstream necking machine and the downstream packaging machine so that, at the end of the production process, all three machines can be optimally operated by just one person; and the presence of a high-quality, industrial designed machine cabin based on the design of tool manufacturing machines.

You can find more information about the LPR-30 at http://bit.ly/SprimagLRP-30.

 

DEVELOPING A PHARMACEUTICAL CLEANING STRATEGY

Cleaning processes are used to remove any product, process-related material and environmental contaminant introduced into equipment as part of the manufacturing stream. Many aspects need to be considered in setting up a cleaning procedure while studying it. The purpose of this e-book is, in fact, to discuss the problems that might be encountered and consequently explain the existing solutions.

 

New requirements are faced by the manufacturers therefore new targets are fixed and the evidence that these are met is shown through successful case studies. This is certainly a multidisciplinary issue that involves various company areas: from “Regulations” to Engineering, from Quality Control lab to Production department. Contributions of all these areas together can lead to a robust and reproducible cleaning process.

 

Cleaning is an essential practice for any pharmaceutical activity. it is impossible to manufacture drugs in dirty conditions, even if soil is not evident. Defining differences between a sterilization and a cleaning treatment is important in order to understand in depth the main problems and peculiarities when defining a cleaning strategy. To sterilize means to destroy or inactivate microorganisms.

 

We know the target and we can define it in terms of a number (CFU/unit) and resistance (D, z). The definition of sterile product/ item (PNSU – Probability of Non-Sterile Unit or SAL – Sterility Assurance Level) is probabilistic but is universally accepted. The kinetics of ordinary sterilization processes are well understood. On the other hand, for a cleaning process, the “enemy” is not defined and in any case can vary on a case-by-case basis: residue of previously processed product, diluents, solvents, various chemicals, lubricants, generic soil, microorganisms, etc.

 

There is no absolute definition of cleanliness. The kinetics of the cleaning procedure is unknown. Consequently, also the definition of “cleaning dose” to be provided is undetermined. In these conditions, even regulatory bodies struggle. Essentially, they allow manufacturers considerable flexibility in establishing their own cleaning specifications. The FDA, for example, does not define methods describing how a cleaning process should be validated. FDA inspectors have to assess the rationale used to set the cleaning limits, making sure that their basis are scientifically justifiable and grounded on adequate knowledge of the materials involved.

Thema4 Process Controller by Fedegari

In order to meet the most demanding pharmaceutical requirements, great care has been taken in designing Thema4 life cycle management: from the conception phase to components selection and definition of system architecture and project management, through the project phase in the development of software according to the FDA CFR 21, part 11, to the current operation phase and the definition of product management procedures (change control, configuration management, support, repair, maintenance, etc.) according to the GAMP guidelines.

 

Now, after continuous improvements of software and hardware components, functions and processes, Thema4 finds itself in the maturity of the operation phase and the reference guideline for its management is the GAMP 5. Several new software versions are released every year that include those developments requested or suggested by our end users.

That’s why investing in a sterilizer with a Thema4 process controller allows the buyer to capitalize on decades of cumulative experience in managing pharmaceutical manufacturing processes developed for the most demanding companies worldwide. An extensive team of experts assures that the controller is constantly innovated and manages all new developments in accordance with the end users needs and the adopted GMP standards.

 

The Thema4 main features and functions will be furtherly explained on our upcoming webinar scheduled to be aired on July 18th at 10:45 AM CST. Basically our Presenter, the newly appointed Automation Director at Fedegari, Massimo Ghelfi, will explain the process controler high performance, fully validated control system, with the highest level of flexibility and configurability to fit all end users needs COTS hardware, reliability and performances.

 

If you are interested in learning what is the process control main application and which products can be integrated into its operation, then this webinar is for you.

Popular New Liquid Packaging Trends in 2018

 

Contract filling and packaging solutions for liquids cover everything from food and non-food substances to over-the-counter (OTC) medications, pharmaceuticals, and more. The large size of different companies in need of these services has introduced new liquid packaging trends that are now being embraced by companies around the world.

Turnkey packaging solutions and multi-layer containers are two such examples commonly found in the current market. Both of these are direct responses to consumer demands and prove that the company selling the product is listening to their customers. Let’s examine all of the latest liquid packaging trends by covering the different benefits each individual trend offers.

The Rise of Turnkey Solutions

Turnkey solutions are becoming the norm for pharmaceutical companies in need of packaging their medications and OTC products. Contract packagers have evolved into a multi-billion dollar industry and their growth is only projected to increase year to year. This is a direct result of their all-in-one services that not only achieve the desired results but at a reduced cost. In other words, it is the better investment for growing companies.

Key benefits include:

  • Cost-reduction
  • Scalability
  • Quality assurance
  • More eco-friendly
  • Maximum value
  • Standard regulation compliance

Tip: Since turnkey solutions are among new liquid packaging trends, more companies are trying to quickly adapt. Choose your turnkey partner by verifying their history and looking for a proven track record of success first.

Creative Custom Packaging Designs

Knowing the consumer market is key when deciding on the package design. For example, organic items have been the preferred choice for consumers across most industries. This preference has revealed a simple pattern in labeling. In essence, the more modest and natural the packaging seems, the more appealing it is to customers.

Other packaging and label preferences include:

  • Functionality (Is it portable/ sealable/ recyclable/ etc.?)
  • Clear / transparency (Can you view the product through the container)
  • Eco-friendly (Does it reduce overall environmental impact)
  • Vintage labeling (Can you revive an older design for nostalgic appeal?)

Tip: The most important aspect to deciding on the packaging design and labeling is to know who you are marketing it to. Bold is not always better and a minimal design strategy can save you money.

Embracing New Technology

The improved capabilities of automated contract filling machines are equally economical and practical. Why potentially risk damaging your product during the filling process when it is unnecessary? The temperature when sealing can damage or negatively affect the product’s quality. Moreover, more companies are in need of small batch product sizes than ever before.

Contract filling services using injection molding technology during the blow, fill, seal process eliminate this risk and new, automated contract filling machines are capable of both full-scale and small batch production. What this means is you can eliminate paying excessive labor costs if you need to.

To learn more about the advantages of contract filling using injection molding, check out Contract Filling Equipment for more information.

 

To discuss these liquid packaging trends or to speak with someone about the advantages of using a turnkey partner connect with us or contact LF of America today.

A member of our team will be more than happy to find the perfect packaging solution that brings your company into its next phase of success.

 

JVNW Pharmaceutical Vessels

The processing of sterile and non-sterile liquids, such as blood plasma have specific purity requirements that can only be achieved with great technical skill and experience. Preparation and pressure vessels from JVNW are built to meet all standards and ensure that our customers ‘central process components’ have competitive advantages. The surfaces of JVNW’s preparation and pressure vessels are ground and polished, and as required, electro-polished. All welds are smoothed to the current GMP-/ FDA-standards and exclude even the smallest cleaning dead spaces.

All vessels can be supplied as stand-alone equipment (stationery or mobile) or as automated process units delivered as fully-functional modules installed on-site that include: agitators; homogenizers; metering and regulating technology; control units; valves and pipe connections. Options for hazardous environments are also available.

JVNW provides high quality storage and transportation vessels made of stainless steel. Each vessel is designed to the specific customer´s requirements. JVNW builds full scrape vessels with off-set turbines, dual motion full scrape tanks with counter-rotating turbine agitators and bottom sweep mix tanks. Fixed position spray-balls are custom drilled to match each tank and are tested for complete Sterilization-In-Place.

Bonfiglioli in Minnesota

 

We are delighted to announce that as of Monday June 25th we will be travelling around Minnesota accompanied by Bonfiglioli’s Product Specialist Piero Polastri.

Due to the opportunity of our Project Managers being in your close proximity, we strongly encourage you giving us a call and getting your name on our site visits calendar.

 

This Bofiglioli Demo Tour will uncover some insights on the just released new SAIL machine.

The Bonfiglioli Engineering SAIL puts Container Closure Integrity Testing, Visual Inspection and HGA all on one tabletop making it the ideal solution to ensure Quality and Safety of Parenteral Packages and verify:

– Presence of leaks

– Headspace gas content

– Absence of visible foreign materials.

It is suitable for in-process control, clinical trials and laboratory use without altering the container features. Testing is quick, reliable and repeatable, and gives consistent results for a comprehensive batch control.

 

SAIL stands for Smart Automated Inspection Laboraty meaning that the machine is an automated inspection laboratory especially designed to conjugate sensitivity performance, productivity as well as flexibility to inspect different container types, sizes and contents. A single machine designed to provide customers with a comprehensive set of benefits.

 

Based upon the Bonfiglioli Engineering state-of-the-art proprietary technologies, SAIL is fully customizable in order to best meet present and future user needs and cover a wide range of inspection requirements.

It is characterized by complete modularity and flexibility, including one or more stations for Automatic Visual Inspection to perform any kind of foreign particles detection, cosmetic analysis and cap control at 360°. Additionally, it can integrate stations for Vacuum-Decay based CCIT and Laser-Based HGA for Oxygen/Moisture/CO2/ Vacuum level control, thus making this product an all in one inspection solution suitable for various production facilities.

 

If you want to get some early insights on the SAIL machine as well as on other products off the Bonfiglioli Engineering product line get in touch with Joe Skorcz at JoeS@Lsi1.com or 312-545-2164.

 

Don’t miss out on the opportunity to be first in line to learn more about the newest innovation in the automation inspection for various containers.

The Most Efficient Unit Dose Packaging Machine Available

 

 

 

 

LF of America offers their brand new PENTAFIL unit dose packaging machine that is capable of filling, sealing, and packing liquids for a variety of different industries. While LF provides contract packaging services for orders small and large and are able to create custom packaging, being part of the Internationally renowned Lameplast Group enables LF to assist companies worldwide. Our latest filling and sealing unit dose packaging machine is named the PentaFill A25. Its impressive capabilities include filling as many as 125 vials between the sizes of 0.33-1.0 ml per minute and 115 vials between the sizes of 2.0-10.0 ml per minute. As such, this efficiency is top of the market and perfect for preparing large distribution orders.
For smaller orders, we utilize a similar, comparable machine named the PentaFill A10.

For huge production lines, We would recommend the PentaFill Twin 25 that is capable to double the performance of the Automated PentaFill A25. The new Twin 25 machine is suitable for Contract filling facilities. These fillers are using injection molding technology combined with the blow, fill, and seal process to give users many added benefits. The best contract packaging companies use the flexibility and efficiency of these automated packaging systems to their advantage. The PentaFill Twin A25 is capable of matching the production output of a BFS machine thus making it perfect for contract fillers.

LF’s unit-dose and automated liquid packaging systems use injection mold technology instead of the “Blow Fill Seal” process. Injection mold technology offers companies various benefits unmatched by blow fill seal machines.

Bonfiglioli Engineering unveiled the brand new SAIL – SMART AUTOMATED INSPECTION LABORATORY for pharmaceutical applications.

Earlier today, Bonfiglioli during the opening hours of this year’s Achema Expo in Frankfurt, Germany unveiled their latest product for the pharma applications. It is capable of performing multiple in line inspections on the same package container. By design it features in line leak detection, visual container inspection and laser analysis.

To learn more about the Smart Automated Inspection Laboratory – SAIL give us a call or contact MarkoV@Lsi1.com

Bonfiglioli Engineering will be attending ACHEMA 2018 trade fair.

 

What makes this year exceptional is the world premiere of a revolutionary product in the inspection field, which will enable the pharmaceutical companies and laboratories to reach an unrivaled competitive advantage never seen before, will take place during the exhibition.

You’ll just have to come and visit Bonfig at Booth C70 – Hall 3.1 by following the “Flexible Production” indications to discover the Bonfiglioli Engineering extraordinary innovation of 2018.

More teasers of the product that will be unveiled at the ACHEMA can be found here: http://www.bonfiglioliengineering.com/news/achema-2018

 

 

Fedegari will be exhibiting their latest developments on contamination control to help customers achieving cost-effectiveness with the best performances in pharma manufacturing.

You will be able to see the integration of different Fedegari processes and technologies, as Fedegari has developed fully integrated robotized solutions for different customers world-wide helping them to achieve the best performances and increasing cost-effectiveness.

Be prepared… you will be pleasantly surprised by this exclusive Italian manufacturer, that has prepared a show that you’ll cherish forever.

For this Achema, Bruno has created an exclusive menu for Fedegari. Bruno’s special dishes express his creativity through the quality of carefully selected ingredients: just as Fedegari does, everyday, when we build our engineered process equipment.

See more about Fedegari’s show roadmap at: https://www.achema.fedegari.com/

Curious? Come and visit Fedegari in Frankfurt, Hall 6.1 – Booth B6

 

Lameplast Group, the parent network of LF of America will be settling in Hall 1.1 D48.

Lot of innovations are waiting for you: new primary plastic containers, the brand new models of Pentafill Filling & Sealing Machines, the global services dedicated to pharmaceutical industries and the newest products ready for the distribution.

A great addition to Lameplast’s services is the new filling department for sterile products with fully-automated filling and packaging lines has been opened, set in Boca Raton Florida. The eco-friendly department has been built according to the best process technologies available, and is currently being reviewed for FDA compliance. The new US based camp should be an exact copy of the Italy based contract filling facility that houses a ISO 5 compliant cleanroom, suitable for aseptic automated filling in their COC Farmaceutici plant in Modena, Italy.

LF is an exceptional company and what makes them unique on the market is the fact that they offer Product Development as part of their services. The actual in lab product development main intent is to improve the flow and specification of the product by customizing it to fit the packaging and delivery method emphasized by LF & Lameplast.

Don’t’ miss them!