Introduction to Single Dose Packaging

The introduction of single dose packaging has become a breakthrough across a diverse variety of applications and industries. Single dose packaging, also known as unit dose packaging, has given hospitals, pharmaceutical companies, and patients more control over their medication while simultaneously reducing waste. It’s also become a popular commodity used by cosmetic manufacturers due to its small, easy to carry unit size.

So what makes unit dose packaging such an innovative development in the packing field? What benefits does single dose packaging provide companies and how is it best utilized? The purpose of this article is to answer these questions thoroughly while covering the many advantages incorporating unit dose packaging in various applications. Keep reading to learn why a unit dose delivery system might be perfect for your product.

Advantages of Single Dose Packaging

As implied by its name, a single dose package safely holds a single premeasured unit of a particular medicine or substance. Having a dose already measured out eliminates the possibility of human error while adding convenience for the user during application. Moreover, its materials are made of eco-friendly bioplasticfrom 100% renewable sources, reducing our dependence on diminishing resources and lessening waste.

The advantages of single dose packaging in clinical and hospital settings are as follows:

  • Improved application accuracy for patients and personnel
  • Reduction in waste and unnecessary bottles and containers
  • Barcodes that identify each individual dose
  • Easily identifying tampered or broken packages
  • Patient is only responsible for exact doses delivered
  • Simple electronic documentation capabilities

There is an obvious advantage for people to have their medication already measured out prior to administration. There are, however, also other advantageous benefits that have since become widely utilized by other forward-thinking businesses in a wide range of other industries. Because of its diverse functionality, unit dose packaging is also now commonly found utilized in cosmetics, OTC products, veterinary and animal care, and even diagnostics.

More Single Dose Packaging Applications:

In cosmetics, health and beauty products are often handed out as samples for consumers to try. Utilizing the convenient size and protection of unit dose packaging, handing out lotion, gel, perfume, or other samples in an easy-to-carry, premeasured package has never been more effective. Similarly, diagnostic test kits in single dose containers eliminate potential human error while increasing the convenience for personnel.

As more businesses discuss the benefits of incorporating innovative packaging into their brand, surely even more uses will continue to develop. One such recent market that has grown to embrace its advantages is packaging for CBD products. If you, too, believe unit dose packaging might be right for your product or application, contact us today. We’ll gladly assist you and tell you how to receive some free samples filled with your product. Call 800-829-5741

PDA Conference: Learn the latest in testing innovations

Bonfiglioli Engineering, is delighted to announce its participation at PDA Europe Parenteral Packaging Conference, that will be held on March 19-20 2019 at the beautiful location of Hilton Molino Stucky in Venice, Italy.

The conference brings together industry and regulatory experts to share their experiences, new developments, regulatory considerations, trends and best practices in the field of parenteral drugs.

During the 2 days event, Bonfiglioli Engineering will welcome you at tabletop # 9 and at the  scientific poster session to discover the latest innovations in non destructive, non invasive Container Closure Integrity Testing, Visual Inspection and Headspace Gas Analysis for Laboratory and In-line pharmaceutical packaging markets solutions.

The equipment is also available for demos in the US so get in touch with our sales reps and we’ll make sure to include you in our meeting agenda.

Vetromeccanica’s TableTop system – Conveyor of Peerless flexibility

Vetromeccanica is well known and widely respected for their Table Top conveyance systems. Their TableTop conveyor system offers a versatile design, which makes it a popular conveyor system suited for a wide range of high-speed production environments. Their TableTop conveyor systems are built to work almost anywhere in your production line.

Known for their quick deliver time, fast and easy install and cheap operational fees, Vetro’s Table top systems provide the biggest bang for the buck.

The flat top plates are stronger than modular belting and transport items through production more efficiently and safely.

TableTop conveyors have excellent flexibility for production line layouts, being suitable for curves or changes in elevation, thus streamlining factory operations.

The flexibility often stands out when a production line needs a versatile solution that can serve your transporting, merging, diverting or accumulation problems.

Key Features of the standard Bench Top / Table Top conveyance models:

  • Low friction values
  • High resistance to wear
  • Low noise level
  • Wide chain applications
  • Stronger chain configurations
  • Easily integrate with existing systems
  • Low Power Consumption
  • Easy To Install
  • Easy To Clean
  • Small Foot Print

Get in touch with our office now and schedule a call or a meeting help us better understand your conveyance needs, so we can estimate your project challenges up to the tiniest detail.

The most versatile testing solution available

The SAIL is Bonfiglioli’s new automated inspection laboratory for different container types, sizes, and content bringing together CCIT, AVI and HGA technologies is an all-in-one machine that is suitable for in-process control, clinical trials, and laboratory use.

HIGHLIGHTS

 SAIL modular structure provides adequate flexibility upon all 3 of testing technologies:

– AVI (Automatic Visual Inspection)/ SAVI a collection of images is acquired using high resolution matrix cameras under designed illumination conditions.

– CCIT (Container Closure Integrity Testing) non-destructive integrity testing in packages by Vacuum Decay Method.

– HGA (Headspace Gas Analysis) inspection process is based on the Tunable Diode Laser Absorption Spectroscopy (TDLAS) method which accurately quantifies gaseous concentration levels.

• All in one Industry 4.0 based
   laboratory
• Ergonomic workstation
• Scientific and objective inspection
• 100% traceability
• Time & cost saving

SAIL modular structure provides adequate flexibility for all 3 testing technologies:

– AVI (Automatic Visual Inspection) /SAVI

– CCIT (Container Closure Integrity Testing)

– HGA (Headspace Gas Analysis)

The testing methods conform to current pharmaceutical regulations, such as FDA 21 CFR Part 11 and EU Annex 11USP General Chapter <790>ASTM F2338-09USP General Chapter <1207>EU Annex 15 and GMP requirements.

Contact our offices today to learn more about the SAIL.

CLEANING GUIDELINES VALVE ASSEMBLES AND SYRINGES

Regularly scheduled preventive maintenance minimizes downtime and assures trouble-free operation!M

Cozzoli’s exclusive sliding valve assemblies and precision honed syringes are mated for life and operate as matched sets on liquid fillers.

Each set is engraved with matching serial numbers that correspond accordingly. It’s important never to mix up or interchange designated serial numbers with other valves and syringes, as damage and poor operational permanence will result.

DISASSEMBLE AND ASSEMBLE

When disassembling, always withdraw the piston in a straight, horizontal line in reference to the valve or the syringe body.

Reverse this procedure to assemble.

Never use force, as it will cause the components to jam.

BEFORE USING

Before the initial use of valve assemblies and syringes, clean and rinse with a solution of soap and water, then flush thoroughly with clean water.

Place them on a lint-free cloth or paper.

Do not allow components to come in contact with contaminants or other metal parts after cleaning.

AFTER USING

Product should not be allowed to dry in the valves and syringes since it could cause them to score or seize.

Always disassemble them and clean properly with an appropriate solution that will remove product.

A bristle brush with a plastic center may be used. Blow dry components thoroughly to ensure that they are free of foreign particles and watermarks. When autoclaving, be sure that the piston is removed from the valve or syringe body.

WHILE IN OPERATION

Valves and syringes should never run dry while in operation. Either product or water must be present.

HANDLE WITH CARE

Proper valve and syringe handling is essential. Dropping, hammering on or restraining them in a vise may damage and render them inoperable.

PRIOR TO INSTALLATION

Check action of valve and piston within syringe cylinder to ensure smooth performance prior to installing on filler.

STORAGE

Between uses, valves and syringes to be stored wrapped in a lint-free cloth or paper.

This is necessary to avoid contamination and contact with other metal components.

Contact our offices to learn more about Cozzoli Machine Company and their comprehensive product line.

Table top Container Closure Integrity Tester

The LF-S11 by Bonfiglioli is a countertop compact machine, designed for Non-Invasive, Non-Destructive Container Closure Integrity Testing of diverse types of Pharmaceutical Containers filled with liquid, lyo, powders, etc..

Suitable for In-Process Control and Laboratory use without altering container and/or content features.

The integrated software system allows full compliance to provisions stated in FDA 21 CFR part 11 as well as EMA Annex 11.

3 Configurations of the machine available to meet all specific requirements:

– BASIC, for most of the container formats 

– XL, designed specifically for large formats (more than 100ml)

– SY, designed for syringes, carpoules including automatic plunger stopping device

Equipment test method complies with:

– FDA Guidance for Industry “Container and Closure System Integrity Testing in Lieu of Sterility Testing as a Component of the Stability Protocol for Sterile Products”.

– United States Pharmacopoeia General Chapter «1207» “Packaging Integrity Evaluation”.

– EU Guidelines to GMP Medicinal Products for Human and Veterinary Use – Annex 1 “Manufacture of Sterile Medicinal Products”.

– PDA Technical Report No. 27 “Pharmaceutical Package Integrity”

All dedicated test chambers are designed according to the container characteristics for a maximum of leak detection sensitivity and are monitored by specially developed electronics during the testing process. The group has been recently redesigned to obtain improved functionality (quick

 single-handed opening and closing). It is directly installed onto the Testing Chamber supporting flange and it is composed by: – A fixed bottom part; – A removable top cap (upper part) that allows plugging up the testing group corresponding to Container loading and unloading operations.

HOW IT WORKS

The test chamber fixed bottom part is equipped with a mobile piston, plunger stopping device (PSD), having vertical motion between two limit positions, “upper” and “lower”, and having a section equal to that of the PFS plunger.

The initial vacuum, generated in the test chamber, produces an upward movement of the PSD.

The same “upper” position is kept until the second reading; at that time, the action of a dedicated pneumatic actuator provides for exhaust of vacuum in the test chamber bottom area and produces the PSD downward movement towards the “lower” position.

For more information, please call our office and we’ll be happy to assist.

Walk in Chambers – The future of storage

Bahnson Environmental specialties designs, manufactures, installs, and services custom chambers of all types and sizes, for a wide array of applications, including: GMP Shelf-Life Testing and Storage, Dry/Moist and Cold Storage for Seed and Agricultural Products, Nutritional Supplements, General Materials Testing, Mold and Fungal Incubation, Photography Storage, Concrete Curing, Roll-In Bottle Incubation Chambers and Cold storage solutions.

They are part of the EMCOR group a fortune 500 company with over 40 years of extensive experience in the field, providing the most resource-saving technologies in liquid-circuited cooling systems to ultrasonic humidification.

When custom solutions are required, the engineering team has the training and experience to ensure that optimal performance does not sacrifice energy efficiency. In their comprehensive experience they have encountered facilities that had lost multi-million dollar worth of research due to freezer or consolidated chamber failures.

In the recent years, Bahnson Environmental have become advocates for installing a consolidated walk in chamber over solving your storage problems by adding a new stand-alone freezer and ending up with the so called freezer farm.

The debate of Freezer farm vs Consolidated Storage has been showcased on our webinar series. Some of the more specific conclusions reached on that show were:

  • Freezer Farms are cheaper to be bought and are easier to be installed
  • Freezers are more prone to failures over Consolidated walk in chambers
  • Freezer farms have significantly higher maintenance fees
  • Freezers are less power efficient than consolidated walk in chambers
  • Freezers often have no to low fail safe assurance technology
  • There are no minimal or maximal space requirements in installing walk in chamber
  • Under some external third party studies 4 common ultra low freezers have the same power efficiency grade as a walk in chamber 20 times that size in volume

Bahnson’s standard and custom environmental chambers / rooms include:

  • Walk-in temperature and humidity chambers
  • Walk-in warm rooms
  • Walk-in cold rooms
  • Walk-in freezers
  • Walk-in incubators
  • ICH stability chambers
  • Shelf life study chambers
  • HEPA filtered clean cold rooms
  • HEPA filtered clean warm rooms
  • Test chambers
  • Plant growth chambers
  • Shelf lighted rooms
  • 1% and 2% dry rooms
  • Other low humidity dry rooms

These are just a sampling of room types included in the walk-in environmental chamber series.

In the pharmaceutical market, Bahnson is determined and focused on stability rooms, that strive on meeting and exceeding the ranges and uniformities of the ICH has allowed Bahnson to become the recognized leader in chamber design, construction, and stringent performance qualification in support of our clients’ validation.

Bahnson is also a well know brand that supplies universities, medical schools, and industrial customers with chambers requiring uniform dependable room conditions for storage and testing experiments.

Their comprehensive resume includes some of the largest installations of multiple environmental rooms in notable research buildings on campuses throughout the US.

 

Get in touch with our project engineer at 800-829-5741.

 

Cosmetic Filling And Packaging

LF of America provides cosmetic filling and packaging services for a variety of liquids, creams, lotions, serums, and powders. Our cosmetic contract filling services are done using state-of-the-art liquid filling machines that are can be used for small batch orders all the way up to large-scale production sizes.

We also provide a wide variety of different cosmetic packaging options that will perfectly accommodate your product so that it is safe for distribution and appealing to consumers. The cosmetic packaging options we provide include everything from unit-dose packaging for easy, precise delivery to dual chamber bottles with tamper evident caps, and more.

Find out more about what is all included in our cosmetic filling and packaging services below. To get started today, contact LF of America and let us prove to you why we are the best turnkey partners in the cosmetic filling and packaging industry.

 

LF of America is proud to say that contract filling for cosmetics is one of our primary specialties. We take great pride in our impressive ability to fill and seal cosmetic products in accordance with the best industry practices for assured product safety and quality.

The process is performed on-site in our state of the art facility, which houses advanced liquid filling machines in completely controlled areas. Our ISO-8 cleanroom is in accordance with all Cosmetic GMP regulatory guidelines, extending from the Quality System Requirements for medical devices.

The filling machines for cosmetic liquids and creams can handle most liquid viscosities and the line speeds can work at different rates, meaning no order is too big or small or us to handle. In addition, we are capable of filling your own packaging design or you can choose one of our cosmetic packaging options.

These packaging options include unit-dose packaging for cosmetics, wand tubes with hypoallergenic applicators, dual chamber bottles, bottle with droppers, enema containers, containers for vaginal use, and the diversely unique Bellow Bottles complete with various applicators and different size cannulas.

Turnkey Cosmetic Filling And Packaging Services

Our cosmetic filling and packaging services are truly all-inclusive and include everything from formulation, batching, packaging selection, and filling. We also offer packaging manufacturing and provide custom packaging options where we will hot stamp, emboss, and label, and pad print your product before distribution.

It is our mission to guarantee satisfaction for our customers and our shared goal is to help our clients succeed in their venture, however big or small. Whether your need is to test out a new line or prepare a best selling product to meet consumer demand, our cosmetic filling and packaging services can help you get it done quickly and affordably.

Give us a call to ask us more about the premier choice in contract filling at 800-829-5741 to get started today.

 

AirTech – BENEFITS OF VETROMECCANICA’S AIR CONVEYORS

Air conveyor belts are highly recommended to convey empty PET bottles/containers without damaging them.
Vetromeccanica’s air conveyor belt guarantees the hygienic, gentle and safe handling of empty PET bottles even at high speed, indeed.

The Air conveyor has been Vetro’s flagship model since their launch in 1992. It is a solution that they have delivered to hundreds of customers in more than 70 countries worldwide. The AirTech system it The model that is designed and built only by Vetromeccanica and listed below are some of the key features and benefits of running an Air conveyor over any other solution.

– FAST AND FLEXIBLE ARRANGEMENT 
AirTech can be easily installed on the wall, on the ceiling or on the floor according to the production plant needs, structure and resources

– EASY AND FAST FORMAT CHANGE-OVER  
Thanks to its special guides adjustment system this air conveyor belt can handle every bottle format, as it utilizes an approach of hanging the bottles down holding by the neck of the PET bottle.

– AIR FLOW ADJUSTMENT 

According to the bottle format to be conveyed. This feature can be used as a clinical buffer when you need to diverse or accumulate a minimal or maximal line accumulation.

– INTUITIVE AND TOUCH SCREEN HMI 
Facilitated monitoring operations and adjustments: intuitive and easy to use HMI.

– MINIMAL MAINTENANCE COSTS

Mainly because the whole guidance system is built from stainless steel and the deteriorating elements are reduced to the bare minimum.

– ENERGY SAVING LOGIC
Reduced energy consumption of just having a couple of fan blowers to convey your complete line over motors and drivers that run a belt operated standard conveyor

– AIRTECH CAN HANDLE CONTAINERS EVEN IN CASE OF HEAVY SLOPES

Vetromeccanica has built air conveyance solutions that housed elevators, lowerators, spirals and other stems used in multi level production plants. Their air conveyor is powerful enough to lift filled bottles up and down the heaviest slopes.

 

If conveyance is in your area of interest and you want to learn how this system can be connected to your manufacturing process, give us a call now and we’ll be happy to assist.

THEMA4: THE SAME TECHNOLOGY BEHIND NASA MISSIONS

The success of Fedegari process control Thema4 is based on the same technology used by NASA for over 20 years: Wind River‘s® real time operational system VXWorks.

For nearly 25 years, Wind River® has provided NASA with the most proven software platform to bring dozens of unmanned systems to space, resulting in some of the most significant space missions in history.

Wind River provides the intelligence that enables these systems to connect data and perform with determinism, precision, and reliability.

Our most demanding customers recognize that only a reliable and accurate control of sterile processing can guarantee the highest perfomances and the safest operations while assuring data integrity.

Fedegari system is:

– not subject to cyber attacks;

– stable over time – considering Fedegari machines life cycle of about 25-30 years;

– a closed system that does not allow to make changes compromising security.

Learn more:

Thema4

Thema4 integration with customers IT network 

 

https://youtu.be/0PWpqmYW-Og

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