Liquid Vial Filling Machines

Cozzoli offers a wide range of automatic vial filling machines for the pharmaceutical industry. Capable of handling vial sizes up to 100 ml and speeds up to 400 per minute, our vial filling machines can be customized to fit any of your liquid vial filling needs.

FSV50 – Filling & Stoppering Machine

The FSV series is ideal for applications where space is an issue. With hood isolation and laminar flow in mind, this machine utilizes the least amount of space for use in a clean environment. This machine will fill liquids or powders, then stopper the containers using full or partial stopper insertion. Speeds of up to 50 containers per minute with a fill accuracy of +/- .5% can be achieved with the FSV.

RFPC – Filling, Plugging and Capping

The RFPC series can handle various container shapes and sizes and a wide range of products from aqueous to heavy oils, suspensions and creams. RFPC models permit pre-programming container size and fill volume with visual on-screen data and diagnostic reporting. This machine can be equipped with 1-4 nozzles and is capable of filling up to 200 vials per minute with a fill accuracy of +/- .5%.

CR Series – Filling & Stoppering Machine

The CR Series provides continuous-motion filling and stoppering. Offering production speeds up to 200 and 400 containers per minute, this machine performs with outstanding fill accuracy of +/- .5% or better, with either full or partial insertion of stoppers.

VR Series – Liquid Filling Machine

The VR Filler Series encompasses different models to accommodate a variety of applications. They operate in an intermittent mode ranging from moderate to high speeds. Solid, reliable performance at low to high speeds with smooth, efficient container handling. This series can be equipped with 2-16 nozzles that fill up to 300 containers per minute, with a fill accuracy of +/- .5%.

F400X – Tabletop Filler

Perfect for low production rates with high accuracy requirements. Fills aqueous solutions to light oils. This product is shipped fully assembled and ready to use. It can fill up to 50 containers a minute, depending on the operator, with an accuracy of +/- .5%.

LSI Manufacturers for 2020

Since 1992, Life Scientific has consulted on more than 5,000 equipment opportunities with industry-leading clients in Pharmaceutical, Biotech, Medical Device and Industrial markets. 

Feel free to visit our website and draw upon our extensive resources. We offer you access to our network of organizations that represent a staff of well over 1,000 people.

Without any further ado, we’d like to introduce our list of manufacturers we are currently representing:

Aseptic Enclosures located in St Louis, Missouri manufactures a wide range of Air Filtration equipment for Aseptic processing and Containment applications. Additionally, we offer a broad range of supplies and services to support the operation of Aseptic processing and containment facilities. We believe infection is a significant global issue and are determined to support you in your efforts to control it!

Bahnson Environmental Specialties produces Reach-In and Walk-In Stability Chambers, Photostability Chambers, Vaccine Storage Custom Freezers and Environmental Chambers.
Performance testing and documentation packages are readily available for all installations. Bahnson offers pre-site testing, level II field testing and level III total documentation packages. Design Built Custom Units can be provided for unique applications.

Bonfiglioli Engineering has developed advanced expertise in terms of Leak Detection, Visual Inspection, and Headspace Gas Analysis ensuring both the quality and safety of a wide variety of package systems filled with liquid and freeze-dried sterile products. An array of state-of-the-art solutions ranging from laboratory to high-speed production scale are providing robust, reliable, repeatable, and quantitative results. On the other hand, proficient project teams with both quality culture and thorough experience in research, innovation, design, manufacturing, and validation provide for compliance with standards, guidelines and regulatory requirements of all equipment and computerized systems. Bonfiglioli Engineering claims durable and proactive collaboration with major pharmaceutical industry regulators such as FDA, EMEA and effective cooperation with global associations including BFS IOA, ISPE, PDA.

For over a century, Cozzoli Machine Company MRM/Elgin has provided technologically advanced machinery for the packaging industry. Cozzoli’s expertise lies in aseptic and non aseptic pharmaceutical, cosmetic, health, and beauty aids. MRM/Elgin specializes in personal care, food, beverage, chemical, paint, and industrial products. From individual machines to complete lines, we are your complete source for equipment and full-service capabilities.

Fedegari Autoclavi SpA, located in Albuzzano, PV (Italy) is the holding company of the Italian industrial group that manufactures machines, systems, components and provides services in the field of sterilization, chemical bio-decontamination and contamination control for the biopharmaceutical and food industry worldwide. Fedegari was created by brothers Giampiero and Fortunato Fedegari in the early 1950s in Pavia as a small handicraft company dedicated to the manufacture of various structural items. Later it developed in the production of sterilizers, gradually specializing in the design of these machines for application in the pharmaceutical field.

LF of America Corp. is an exceptional company that fills, packages and distributes unique unit dose and multi-dose plastic containers for the Health & Beauty industry. LF of America is with you for as little or as much as you like from container selection to filling to fulfillment services, and more. From small to large-scale orders, you can always count on LF of America for innovation and reliability.

Mesa Labs develops, manufactures and markets, high-quality process validation and monitoring instruments and consumables. From Fortune 500 companies to high tech start-ups, Mesa Lab’s products are used to assure product quality, control manufacturing processes, and to solve problems in niche markets in healthcare, industrial, pharmaceutical, medical and food processing applications.

Over the years, Newman has built up an enviable reputation for high quality labelling equipment to meet the specific regulatory regime demanded by the international pharmaceutical industry. The secret behind our success can be put down to a combination of quality of service, accuracy and reliability of equipment, quality and speed of validation, capability of engineers and staff experience, and the stability of the company.

Vetromeccanica designs and builds conveyance systems for primary and secondary packaging. Vetromeccaninca is a global producer with sales, service and parts distribution offices in the US, and installations in over 70 countries.
They are famous for their Automatic Line Control Geo-synch “Synchro” Systems. It’s mostly suitable to eliminate product gaps by controlling carefully container flow before entering decapper, rinser, filler or labeler. The customers profit can be measured in terms of space and energy costs when deciding to include Vetro’s Syncro system in their Semi and Fully Automated Production Lines.

Interested in obtaining further information regarding some of the manufacturers? Or getting your company represented by us?

Please contact us at 800-829-5741

Newman Labelling CTE450

The CTE450 is a fully automatic labelling system that applies a wide range of self-adhesive tamper-evident labels, anti-counterfeit and hologram labels to erected cartons.

It has been designed primarily for the pharmaceutical industry where high levels of production efficiency will be a prerequisite for the introduction of Track and Trace systems onto existing packaging lines compatible with the EU Falsified Medicines Directive and other global Serialisation initiatives.

The CTE450 is also highly energy-efficient, compact and incorporates full Newman ‘validation-friendly’ specifications.

At the infeed, cartons are separated, held between top and bottom belts, past the Print and Inspect station where Serialised codes can be printed and then verified by a Vision system. Cartons are then transported past two stepper motor-driven label stations. Labels are dispensed on to the overhanging vertical faces of the carton and applied with a roller. Airplane and reverse tuck formats can be accommodated. Cartons proceed to the sensing station where sensors detect label presence prior to wipe down. Both labels must be present for a carton to be accepted; if not, it is ejected into a secure reject area

Features

  • Track and Trace Serialisation capability
  • Compact GMP Design with stainless steel finish
  • In-Process Control
  • “Positive accept” security system
  • Automatic critical device checking
  • Twin reject bins
  • Reject verification
  • Product and reject the counter package
  • Validation Documentation Package
  • Low energy consumption

To request further information or the latest pricing give us a call at: 800-829-5741

Fedegari BIO-DECONTAMINATION UNIT – FCDV

With the FCDV bio-decontamination unit you can bring inside the clean rooms all those products and instruments that cannot be thermally sterilized. Surface bio-decontamination of the load is carried out with vaporized hydrogen peroxide – H2O2.

Among the most reliable sporicidal agents, vaporized hydrogen peroxide (H2O2) is nowadays one of the most popular: its antibacterial, antimycotic and antiviral properties are well known and scientifically documented.

This solution is becoming increasingly relevant as the regulators shift their focus away from traditional moist- and dry-heat sterilization processes to address all other bioburden risks. Moreover, Fedegari has applied the Quality-by-design concept to the development of this innovative process equipment, in order to meet the current approach required by the EMA and FDA.

DESIGN & TECHNICAL FEATURES

  • Stainless steel AISI 316L chamber polished to strict sanitary standards (Ra <0.4μm).
  • Doors are made of AISI 316L stainless steel with a central glass panel
  • 100% air-tight guarantee: thanks to two separate inflatable gaskets seating in two slots mechanically machined all around the door with an additional leak-monitoring system.
  • Direct control of hydrogen peroxide in the chamber.
  • Optimized process: surface bio-decontamination is achieved in 30 minutes.
  • Fedegari hydrogen peroxide vaporizer with a control loop (PID based), which provides superior reliability and repeatability for easier validation.
  • Great flexibility: FCDV can be used as a pass-through hatch aired with synchronized doors and pressure control.

To acquire further information or to request a special quote, please call our office at 800-829-5741.

F400X PRICING DISCOUNT

The Cozzoli F400X-SS (stainless steel) single-piston filler is ideal for filling liquids at low production rates with high accuracy. The patented slide valve allows this machine to dispense a wide range of liquids from aqueous solutions to light oils. It is designed for rapid changeover and the positive slide valve action allows the product to be supplied under positive head pressure, allowing overhead or remote supply tank location.

This machine functions on a 2” (50.8mm) operating stroke with maximum cycling capability of 60 cycles per minute. A footswitch is provided for direct operator control, or the machine can be set to automatically dispense liquid at selected time intervals. The syringes operate without O-rings or packings, avoiding the possibility of product contamination. These liquid contact parts are easy to disassemble for cleaning and sterilization. The product is filled under positive head pressure made possible by the exclusive Cozzoli patented sliding-type valve. A drawback control feature eliminates a hanging drop at the completion of each fill cycle.

The F400X-SS has a calibrated volume selector arm for simple adjustments to achieve accuracies of +\- 0.5% of volume or better, with fill volumes up to 60ml. This filler is easy to clean and sterilize— all parts which come into contact with the product are manufactured of stainless steel, and easily disassembled for autoclaving.

Beginning today, pick up an F400X tabletop filling machine for 15% OFF our regular pricing. If you are in the market for a new tabletop filler, don’t wait, because this promotion is only available until the end of 2019.

ES2000 reach-in stability chambers

Bahnson Environmental Specialties’ ES2000 Series chambers are recognized throughout the industry for their durability.

They offer a premium product that our customers can trust to perform day-after-day — for decades.

The Environmental Specialties ES2000 environmental chambers are designed for high demand testing, processing, conditioning, or stability applications

Typical reach-in chamber uses include ICH stability, shelf life studies, incubators, tissue culture storage, freeze-thaw, blast freezing, and other product testing and/or stability storage.
It utilizes a very user friendly touchscreen control system that provides process control, process alarms and circuit switching.
The units are equipped with high performance electronic and mechanical systems capable of accelerated heating, cooling and recovery rates.

The operational Temperature can range 10-70°C and the Humidity levels range between 10-96%.

There are variations of the chamber where it can be a photostability chamber, with the addition of the light banks and sensors to truly make it an environmental chamber.


The following link provides additional information from the instruction manual or original manufacturer’s brochure.

https://www.eschambers.com/application/files/2615/1088/9565/BES_PhotoStabChmbr_broch_120917.pdf

Fedegari FOWS Series

FOWS washer-sterilizer is the first and only machine able to washsterilize/decontaminate and dry different materials used in pharmaceutical production in a single process. This equipment is suitable for the Food, Bio-Pharmaceutical, and Cosmetic industries.

Its peculiarity is represented by the possibility of bringing together in a single process the entire washing and sterilization cycle of equipment and equipment used in controlled contamination environments.

Even with the typical characteristics of a washing machine, the washer-sterilizer maintains all the peculiarities characteristic of an autoclave and can also be used for the saturated steam sterilization process only.

The advantages deriving from this process flexibility are manifold, starting from the smaller area occupied by the machine, passing through the reduction of process times and the costs of the personnel used to arrive at a lower cost for process validation, staff training, and maintenance on the machine.

The FOWS is COMPLIANT with:

  • Standard UNI EN ISO: 9001: 2015, 13485: 2016
  • European Directives: 2014/68 / EU – Pressure Devices (PED), 2006/42 / EC – Machinery Safety, 2014/30 / EU – Electromagnetic Compatibility, 2014/35 / EU – Low Voltage Devices
  • European standards: EN ISO 12100, EN ISO 13857, EN ISO 13849-1, EN 55011, EN 61000-4-2, EN 61000-4-4, EN 61000-6-2, EN 61000-6-4, EN 60204 -1
  • ASME: Stamp R, Stamp S, Stamp U
  • Chinese standard: SELO
  • Swiss standard: SR 930.114
  • FDA
  • GMP

Would you like to know more about the Fedegari FOWS series? Contact us at 800-829-5741.

Unit Dose Packaging Manufacturers

The development of single dose packaging has been a breakthrough for unit dose packaging manufacturers. Single dose packaging or unit dose packaging has a variety of applications that can be beneficial for multiple industries.

Hospitals, pharmaceutical companies, and patients have greater control over medication and, additionally, reducing waste. What are the incredible benefits of unit dose packaging and why is it such a revolutionary development in the contract packaging industry?

The following article will detail this and highlight why the unit dose delivery system may be perfect for your product. If you have any more questions about unit dose packaging or would like to speak with our available packaging options and contract filling services, please contact LF of America

About Unit Dose Packaging

The name unit dose packaging refers to the single premeasured unit of a medicine or substance that the packaging holds. By pre-measuring the dose, the possibility of human error is drastically reduced.

Additionally, it makes the application much easier and comfortable for the user. All the materials used by unit dose packaging manufacturers like LF of America are also made of an eco-friendly bioplastic. 

Clinical and hospital settings can benefit greatly from the innovative single dose packaging development. Patients and personnel can enjoy improved application accuracy in addition to exact dose delivery.

Barcodes are placed on each unit that can easily identify each individual dose. In the event that the package is damaged or tampered with in any way, patients and personnel can identify it immediately.

As mentioned above, unit dose packaging reduces waste and is made from fully renewable resources. Unit dose packaging also makes documentation convenient by providing simple electronic documentation capabilities. 

Manufacturers of unit dose packaging provide numerous benefits for patients by having medication pre-measured prior to application. Unit dose packaging is highly versatile and also provides numerous benefits for other industries.

Amongst other applications, single dose packaging can be found in OTC pharmaceutical products, veterinary care, diagnostics, and cosmetics. 

Additional Benefits of Single Dose Packaging

Many health products provide samples for customers to try. Single dose packaging’s size and ability to protect its content makes it perfect for samples. Diagnostic test kits in unit dose containers are able to completely eliminate the possibility of human error while simultaneously improving personnel convenience. 

More forward-thinking businesses have begun discussing how to incorporate this revolutionary development. The convenient size of unit dose packaging and protection can make handing out gel, perfume, lotion, and other samples easier than ever before. 

One of the most recent industries to begin contacting unit dose packaging manufacturers is the CBD industry. Whether its medication, cosmetics, or CBD packaging, single dose packaging provides benefits like no other packaging method before it.

If you are interested in incorporating unit dose packaging for your business, please contact us today. We will gladly assist you and answer any questions you may have. We will also be happy to provide free samples filled with your product. 

Advancing Personal Care Filling

Cozzoli specializes in providing complete filling and capping solutions for all cosmetic, health, beauty aids, and personal care packaging applications.

From automatic fillers with a speed of 200 bpm or a small tabletop unit for lower production, Cozzoli has a range of fillers to fit your needs.

Choose from a variety of personal care filling methods to meet your production goals.

Cozzoli offers inline or rotary filling with piston, peristaltic pump, diaphragm pump or time pressure technology. Our machines handle a broad range of container shapes and fill viscosities from aqueous to heavy creams.

Choose continuous or intermittent motion, stand-alone or monoblock configuration. Every Cozzoli filler provides unmatched ease of container handling and change-over.

These fillers perform with outstanding accuracies of +/- 0.5% or better of fill volumes.

To find more about the Cozzoli cosmetic and personal care solutions please head over to the products section or call our corporate office.

Turn-key integrated solution Case Study

Case Study: when one of the biggest European tuna can producers was losing cans to uneven heat distribution in processing, Fedegari developed a turn-key integrated solution that resulted in 0 rejected cans.

The challenge

Overcoming undesirable temperature fluctuations and overheating, guaranteeing homogeneous heat distribution throughout the load. · Developing a fully integrated solution for treating different tuna can formats, increasing productivity and, consequently, reducing operating costs.

The context

The nutritional quality of the products as well as microbiological and sensory quality are essential factors in the food industry. The thermal processing of canned food is the most important step in the canning procedure1 . Currently, a large quantity of canned goods is rejected during production and has to be destroyed or reprocessed due to inefficient performances of sterilization. This increases the energy consumption and other significant food processing costs. 1 Ibrahim M. Ismail, Alaa Fahmy, Ahmed Azab, Magdy Abadir, and Seif-Eddeen K. Fateen. “Optimizing the sterilization process of canned food using temperature distribution studies”IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS). For example, overcooking may cause a weight reduction of the product which obligates the manufacturer to complete the cans with additional product in order to comply with the weight indicated on the labelling. Such practices are costly. Sterilization plays a vital role in the food industry as the final product is intended for human consumption. It also represents a critical process since it may influence the quality and safety of the food. In this context, only optimal processing conditions through the proper application of the F-value approach in sterilization allows to optimize the balance between food safety and quality requirements. It assures an appropriate and homogeneous thermal treatment, thus avoiding over- or undercooking, and consequently maintaining the highest standards for uniformity of texture, flavor, and retention of nutrients.

The solution

Process knowledge applied in the development of a fully integrated solution for food preservation and throughput maximization. Fedegari superheated water sterilizers – FOW series (Fig.1) were chosen for improving process performance and throughput. The choice focused on the simplest, most robust and cost-effective solution for sterilizing at a wide range of temperatures with the shortest process time. Fedegari designed an unique, but completely integrated and accurate system. The key for an outstanding performance is the effective control of temperature and F-value which guarantees the highest uniformity to the sterilization process. Control efficiency eliminates errors and rejected loads while operating cost-effectively. The goal was to guarantee the microbiological target along with thermometric performance, through a new process design capable of offering competitive advantage over conventional alternatives. Besides, an additional concern was raised regarding the packaging quality.

The results

Fedegari has supported the customer, one of the biggest European tuna can producers, with in-depth knowledge in sterilization processes, developing a turn-key integrated solution focused on throughput maximization. The customer has increased its productivity at the end of every cycle and the number of rejected cans has been reduced to zero.

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