How does Vetromeccanica’s Vacuum Conveying Work?

Vacuum Conveying is the process of moving bulk dry materials, such as powders, from place to place within a factory using suction. The material is transferred in a network of tubing from the pickup point or source to the customers’ process. Most Vacuum Conveying System transfer product based on a timed interval to the vacuum receiver. At the end of the timed sequence, the discharge valve can open and the material conveyed can discharge into the process. 

There are two types of vacuum conveying. Dilute phase conveying and Dense phase conveying. 

  • Dilute Phase Conveying the material is entrained in the air stream and the is an almost equal part of air and product. This method is excellent for conveying almost any type of powder-like sugar or flour. 
  • Dense Phase Vacuum Conveying the material is transferred in slugs within the convey tubing. The material moves slower then dilute phase conveying and is an excellent choice for a friable product or a blend of powders. 

Vetrommecanica’s conveying systems differ from others because they increase the real plant efficiency. They are a major player in more than 70 Countries thanks to the care and attentiveness to details, capability to offer a 360° all-rounded service, and to their extremely skilled customer-care department.

Learn more about the conveyance solutions we are currently offering by giving us a call at 800-829-5741

Onion Skin Ampoule Filling and Sealing

A manufacturer of drug and explosive detection equipment for law enforcement, hazmat teams and educational systems.

Cozzoli were approached about a need for filling onion skin style ampoules. These ampoules would be part of a mobile detection system, where after swabbing a potentially contaminated area, the swab is inserted into the pouch and the ampoules are crushed. The chemical inside of the ampoule mixes with the swab and will detect if any drug or explosive residue is present.

This application would require the ampoule to be filled with a small and very precise amount of liquid, then flame sealed.

This was a perfect application for our FPS series ampoule filling and sealing MonoBlock. The application required the filling of 6.70mm x 60mm onion skin tubes with .10 mL -.40 mL of liquid. This would have to be done at a production rate of 45 -50 ampoules per minute. Due to these requirements, the FPS1-OS-SS was chosen for the job.

Our FPS series monoblock fills and seals a variety of ampoule shapes and sizes, at speeds of 15-120 ampoules per minute and a fill accuracy of +/- .5%.

With the fill volume requirements being so small, a peristaltic pump was added in order to feed the liquid into the machine. A peristaltic pump is typically used for very precise filling applications, as well as applications where the liquid is clean/sterile and cannot come into contact with any exposed pump components.

For more information on how we can help with your ampoule filling applications, contact us at 800-829-5741

Fedegari: Advancing aseptic processing

While pharma has made tremendous strides in aseptic processing, the industry still struggles with contamination issues — indicating there is more work to be done. Like all segments of the pharma industry, aseptic manufacturing continues to be transformed by disruptive technologies. With the goals of maintaining compliance, lowering costs, and streamlining processes always at the top of mind for drugmakers, industry vendors are innovating solutions that incorporate the latest trends and capabilities.

“Firms are striving to reduce costs and improve process flexibility, while fundamentally eliminating some of the potential contamination challenges,” says Ben Wylie, senior product manager at ChargePoint Technology.

Pharma may be close to mastering aseptic manufacturing, but innovative tweaks and updates to equipment and operations are helping improve the process even more.

Robots have been a game-changer in the packaging department of facilities, and are now transforming the filling process as well.

“Robotics are progressively more available in aseptic processing due to the flexibility they allow — saving time for the operator who would otherwise need to change parts to fill very different kind of vials, syringes and cartridges,” says Federico Fumagalli, chief commercial officer at Steriline. “With robotics machines, they just have to change a single parameter on the robot to change the whole production process.”

Steriline’s Robotic Vial Filling Machine was designed specifically to address the industry’s growing need for flexibility. According to the company, the machine can be equipped with one or two Stäubli vaporized H2O2 resistant anthropomorphic robotic arms (depending on output requirements), which transport the vials within the machine.

Although Fumagalli says there are pros and cons to using robotics, a cost-benefit analysis favors robots because they can reduce downtime, prevent product loss and decrease waste.

“In case a vial is not correctly stoppered, the robot can repeat the stoppering cycle to complete the process,” he says. “On a traditional machine the vial would be rejected — the content discarded — losing a potential earning, and the company would have to dispose of the waste, incurring further costs. Using a robotic system, the vial could go backwards and be stoppered during a second cycle, without any waste.”

Fedegari Technologies has also been developing ways to combo advanced solutions, including robotics, into one piece of machinery.

“The manufacturing processes of the future will streamline new technologies like robotics, artificial intelligence and IoT, into an increasingly closed and connected production process,” says Jeffrey Siterlet, managing director of Fedegari Technologies in North America. “By linking components, isolating the process and centralizing control, tomorrow’s manufacturing process will facilitate efficiency, safety and compliance while eliminating risk.”

The company’s new washer sterilizer, for example, offers sterilization, washing and bio-decontamination in one solution. The gloveless sealed isolator hosts a GMP robotic arm that can be adapted for different batch sizes and simplifies cleaning requirements needed to enter a controlled-contamination environment.

Single-use solutions continue to play a dominating role in pharma manufacturing innovations and provide a wide variety of benefits.

“As single-use and disposable products become more widely utilized, the manufacturing process becomes more efficient through quicker changeovers and set-up times and drug manufacturers can react more rapidly to product and customer demands,” says Wylie.

ChargePoint recently added two products to its single-use portfolio including the ChargePoint Single Use Passive (SUP) and ChargeBag PE-S with new HiPure ULP7 PE film. Together, the two products are intended to form a high performance, single-use package for the contained and sterile transfer of powders between manufacturing process steps or even facilities.

The company says that the ChargePoint SUP is a disposable version of the passive mating half of the ChargePoint SBV (Split Butterfly Valve) technology, which forms a complete hybrid system to ensure users can take advantage of the benefits of disposable technology.

“Technologies such as SBVs are increasingly replacing traditional open transfer techniques, enabling contained and efficient materials transfers,” Wylie says.

Importantly, single-use innovations are also happening for the final stage of the manufacturing process: Transport.

“As the trend of biologics being manufactured in one location and going through the final fill process in another grows, the need for materials that can withstand manipulation at temperatures down to -86 degrees C continues to accelerate,” says Alex Kakad, product marketing manager for AdvantaPure.

AdvantaSil Ultra Low Temperature Silicone Tubing is designed to remain flexible (as opposed to cracking and leaking fluids) at temperatures as low as -112°C. According to the company, its tubing and molded closure assemblies have glass transition temperatures below -100 °C, allowing for a comfortable safety factor for these demanding applications. This, AdvantaPure says, makes the tubing an optimal choice for applications related to bulk drug storage and transport.

From the first stages of aseptic processing until products exit the factory doors, technology trends are continuing to transform sterile pharma operations.

For further information on products that incorporate this technology please contact our corporate offices and/or sales representatives.

SC50T Screw Cap/Aluminum Sealing Machine

The Cozzoli Screw Capper Model SC50T will cap sizes up to 95mm in diameter. The adjustable torque slip-clutch configuration rotates, giving uniformly tightened caps and preventing cap damage with gentle cap handling.

Configured as an aluminum Sealing machine, the SC50T features a selective two-speed drive to a rotating and reciprocating spindle, with a maximum up-down stroke of 2” or 50.8mm.

The Aluminum Sealer provides uniform roller-sealing of container crimp caps up to 43mm in diameter. In either configuration the SC50T is ideal for clean room lab use or small production facility.

An automatic version of this machine can be mounted on a fully integrated Cozzoli packaging line.

Screw cap configuration: With the cap in position, the operator places the container against a “V” plate. The reciprocating spindles then automatically descends to screw on the cap. Torqueing time can be adjusted from .15 to 10 seconds, thereby accommodating most capping speeds.

Aluminum Seal Configuration: With the cap in position, the operator places the container against a “V” plate. The crimping head that consists of 3 blades and 3 rollers then automatically descends to seal the cap; Crimping time can also be adjusted from .15 seconds to 10 seconds.

For pricing and more details call our corporate office at 800-829-5741.

Mesa Labs Product Release of the Universal Torqo Chuck

Mesa Labs, a global leader in cap torque verification and analytical equipment, is proud to announce the release of its Universal Torqo Chuck.

To be most effective and accurate, torque analyzers are specifically customized for the bottle and cap combination to be tested on the unit. For facilities that test a large variety of cap and bottle combinations, customized tooling for each combination complicates the changeover process in addition to greatly increasing the cost to the end user.

As an increased variety of closure designs have gained prominence and popularity in the industry, Mesa has developed its new Universal Torqo Chuck to accommodate multiple serration patterns and cap sizes with a single change part, compatible with the Torqo torque analyzer (1502-1600).

Tapered to accommodate most 26-32mm OD plastic caps, Mesa’s non-destructive Universal Torqo Chuck is compatible with smooth caps, caps with various serration patterns, and eliminates the need for multiple costly chucks.

Contact us for more information on the Universal Torqo Chuck at 800-829-5741.

Fedegari Integrated Systems

Fedegari has developed fully integrated robotized solutions for different customers world-wide helping them to achieve the best performances and increasing cost-effectiveness.

Fedegari, once known for its sterilizers, has turned today into a one-stop industrial group that delivers highly customized solutions where the bio/pharmaceutical industry is producing sterile drugs.

During the last years, Fedegari has developed fully integrated robotized solutions for different customers world-wide helping them to achieve the best performances and increasing cost-effectiveness.

Hereunder you can find a couple of examples of turn-key integrated systems that we have engineered and developed, together with our customers, to reach the highest levels of cost-effectiveness in their pharmaceutical plants.

No matter the form of the drug, the packaging, or the process, there is always a smarter, more cost-effective alternative in manufacturing.

Contact our Representatives for further information: 800-829-5741

PHARMA TECHNOLOGY FOR LABORATORY SOLUTIONS

More than 60 years manufacturing components, systems and sub-systems in-house for the most demanding users. An in-depth knowledge hard to beat. Fedegari laboratory range offers to customers all the innovation already tested in the pharma industry. The same components, the same process controller, customized to meet specific laboratory needs.

Today, Fedegari is the only manufacturer of lab equipment that is developing its machines by adopting sophisticated solutions already field-tested on the pharmaceutical market by the most demanding users.

Thema4LabTHE PHARMA PROCESS CONTROLLER CUSTOMIZED FOR LAB APPLICATIONS

Engineered and pre-validated by Fedegari according to GAMP 5, Thema4Lab process controller is a revolutionary solution: a completely customized system for laboratory needs that benefits from the pharmaceutical expertise of the industrial Thema4 process controller. This innovative system guarantee a reliable and cost-effective process development and is already available on FOB5 steam sterilizers and FGW glassware washers.

FGW LAB WASHER – FEDEGARI EXPANDS ITS RANGE OF LABORATORY SOLUTIONS 

Fedegari’s latest innovation for laboratory market is a glassware washer that capitalizes the experience acquired with the FOWS-series of washers in the pharmaceutical market. The new FGW lab washer, in fact, uses a steam generator to improve washing performances reducing operating costs. This true eco-friendly solution minimizes the use of detergents as well as water consumption. Not only, the pre-validated Thema4Lab process controller uses a conductivity meter to terminate the process as soon as the desired set point is reached thus further reducing water and other utilities consumption.

The piping, as for any other equipment manufactured by Fedegari, has a rigorous sanitary finishing. The machine is then loaded with a modular, customizable rack that can be easily adapted to all load configurations. As for all Fedegari lab equipment, the FGW complies with cGLP standards. FGW external trolleys are interchangeable with FOB5 steam sterilizers and components are standardized for both machines representing a cost-effective solution for high performance laboratories.

Contact our corporate offices at 800-829-5741 for further information.

Summer Savings for Revamping Your Bonfiglioli Machine!

Take advantage of Bonfiglioli Engineering summer sales!

For your routine machine maintenance and revamping or just ordering spare parts, purchase them before the end of the summer and capitalize on the Bonfiglioli special offer!

When you purchase spare parts during July and Augustyou will benefit from an exclusive 10% discount

Contact us to receive your personal quotation. Call our corporate offices at
800-829-5741.

Opportunities like this don’t come knocking on the door twice!

OFFLINE MULTI HEAD CONTAINER CLOSURE INTEGRITY TESTER

The Bonfiglioli LF-SMH is a versatile offline multi head container closure integrity tester great for labs with space constraints.

This machine is used in various scenarios and settings. It is suitable for:

• Various laboratory applications, statistical purposes as well as off-line testing.
• The Measurement System comprises applying a pressure differential into an airtight Testing Group enclosing the Container (Patent No. 1225063 of 13-9-1988). The test objective is to detect Container leakages by measuring the reached pressure level as well as the pressure change over test time.
• The Measurement System follows the approved industry standard “ASTM F2338-09”:
> The Test method is a Recognised Consensus Standard by the United States Food and Drug Administration (FDA), Center for Devices and Radiological Health (CDRH), effective March 31, 2006 

For more information contact our representatives.

Single Use Pharmaceutical Packaging For Eye Drops

Many forward-thinking companies are always looking for ways to improve their products. Finding practical improvements that benefit consumers in any area of operations has the potential to give pharmaceutical companies an edge over their competitors. One area that many companies are now embracing involve using single use pharmaceutical packaging.

This growing trend for incorporating single use pharmaceutical packaging is being especially embraced by manufacturers of ophthalmic medication like eye drops. There are many useful benefits for using unit dose containers for eye drops instead of the traditional standard dropper bottle.

The following article will highlight the advantages of single use pharmaceutical packaging for ophthalmic medication. It will also provide some information on the innovative pharmaceutical packaging and filling options we have available at LF of America. If you’d like to learn more about our unit dose packaging options or wish to discuss incorporating any of our contract packaging and filling services into your operation, please contact us for more assistance.

Advantages of Single Use Packaging For Eye Drops

Standard eye dropper bottles for ophthalmic medication has been the most common packaging option for countless years. This is predominantly because eye dropper bottles were easy to produce, fill, package, and distribute. However, there are a few common limitations that inspired companies to come up with modern solutions.

Some of these limitations are proper dosing in each eye and shelf-life concerns, which contributes to adding preservatives that create a burning sensation. Fortunately, unit dose packaging for eye drops successfully overcomes these challenges. LF of America is proud to be at the forefront of this development and has patented a specific multi-layer packaging for eye drops.

The benefits of our unit dose packaging for ophthalmic medication include:

  • Preservative Free Formula (No Burning Sensation)
  • Equal Delivery of API (Active Pharmaceutical Ingredient) in Both Eyes
  • Two Piece Unit-Dose Vial with Clean Orifice for Calibrated Drops
  • No Plastic Flashes on Opening to Improve User Experience
  • Injection Molding Technology for Flexibility & Product Safety

Contact our sales representatives via 800-829-5741 to request a free packaging samples for your product.

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