About Marko

Program Your Torque Tester and Get Two Peak Values?

If you would like to program your torque tester and be able to get two distinctive peak torque values (thread break torque and Tamper Evident Band (TEB) break torque), the ST-120S or the ST-S3 torque testers can be programmed as follows:

  1. Associate a product name with the test recipe.
  2. Set the test mode to “Release”.
  3. Set the cycle count to 2. In the first cycle, the machine will measure the peak of the thread break. In the second cycle, the machine will measure the peak of the tamper-evident band (TEB) break.
  4. On the second “Test Setting” screen, set the “rotation speed” to 20rpm, the “release torque limit” to 20lbfin, the “starting torque” to 10%, the “torque ramp” to 30s, and the “method” to the rotation.
  5. Set the “rotation limit” to 250 degrees. Starting with a tight cap (applied torque >10lbfin), the thread break torque can be measured under 30 degrees. However, there is a single rotation limit setting, so the torque limit should be set reasonably close to the peak of the TEB break torque. After a few experimental cycles, the desired rotation limit is 200-250 degrees.
  6. To give the operator time for manually documenting the thread break (1st cycle), go in the Setup/Timers submenu and set the “New Cycle” delay to 5s.
  7. Alternatively, when a computer is capturing data from the machine the new cycle delay can be set to 00:00:50 (500ms).

Click here to view a step-by-step demonstration of this programming.

F400X PRICING DISCOUNT

The Cozzoli F400X-SS (stainless steel) single-piston filler is ideal for filling liquids at low production rates with high accuracy. The patented slide valve allows this machine to dispense a wide range of liquids from aqueous solutions to light oils. It is designed for rapid changeover and the positive slide valve action allows the product to be supplied under positive head pressure, allowing overhead or remote supply tank location.

This machine functions on a 2” (50.8mm) operating stroke with maximum cycling capability of 60 cycles per minute. A footswitch is provided for direct operator control, or the machine can be set to automatically dispense liquid at selected time intervals. The syringes operate without O-rings or packings, avoiding the possibility of product contamination. These liquid contact parts are easy to disassemble for cleaning and sterilization. The product is filled under positive head pressure made possible by the exclusive Cozzoli patented sliding-type valve. A drawback control feature eliminates a hanging drop at the completion of each fill cycle.

The F400X-SS has a calibrated volume selector arm for simple adjustments to achieve accuracies of +\- 0.5% of volume or better, with fill volumes up to 60ml. This filler is easy to clean and sterilize— all parts which come into contact with the product are manufactured of stainless steel, and easily disassembled for autoclaving.

Beginning today, pick up an F400X tabletop filling machine for 15% OFF our regular pricing. If you are in the market for a new tabletop filler, don’t wait, because this promotion is only available until the end of 2019.

Happy Thanksgiving from the LSI team

Dear Life Scientific, Inc. customers, clients, and associates,

Thanksgiving Day is the perfect time to remind one another of the many reasons there are to be grateful. Whether you’re gathered around the table, crafting your Thanksgiving card, or just in need of a little reminder that there have been times when we forgot to thank you for being there for LSI.

Have a memorable Thanksgiving.

ES2000 reach-in stability chambers

Bahnson Environmental Specialties’ ES2000 Series chambers are recognized throughout the industry for their durability.

They offer a premium product that our customers can trust to perform day-after-day — for decades.

The Environmental Specialties ES2000 environmental chambers are designed for high demand testing, processing, conditioning, or stability applications

Typical reach-in chamber uses include ICH stability, shelf life studies, incubators, tissue culture storage, freeze-thaw, blast freezing, and other product testing and/or stability storage.
It utilizes a very user friendly touchscreen control system that provides process control, process alarms and circuit switching.
The units are equipped with high performance electronic and mechanical systems capable of accelerated heating, cooling and recovery rates.

The operational Temperature can range 10-70°C and the Humidity levels range between 10-96%.

There are variations of the chamber where it can be a photostability chamber, with the addition of the light banks and sensors to truly make it an environmental chamber.


The following link provides additional information from the instruction manual or original manufacturer’s brochure.

https://www.eschambers.com/application/files/2615/1088/9565/BES_PhotoStabChmbr_broch_120917.pdf

Fedegari FOWS Series

FOWS washer-sterilizer is the first and only machine able to washsterilize/decontaminate and dry different materials used in pharmaceutical production in a single process. This equipment is suitable for the Food, Bio-Pharmaceutical, and Cosmetic industries.

Its peculiarity is represented by the possibility of bringing together in a single process the entire washing and sterilization cycle of equipment and equipment used in controlled contamination environments.

Even with the typical characteristics of a washing machine, the washer-sterilizer maintains all the peculiarities characteristic of an autoclave and can also be used for the saturated steam sterilization process only.

The advantages deriving from this process flexibility are manifold, starting from the smaller area occupied by the machine, passing through the reduction of process times and the costs of the personnel used to arrive at a lower cost for process validation, staff training, and maintenance on the machine.

The FOWS is COMPLIANT with:

  • Standard UNI EN ISO: 9001: 2015, 13485: 2016
  • European Directives: 2014/68 / EU – Pressure Devices (PED), 2006/42 / EC – Machinery Safety, 2014/30 / EU – Electromagnetic Compatibility, 2014/35 / EU – Low Voltage Devices
  • European standards: EN ISO 12100, EN ISO 13857, EN ISO 13849-1, EN 55011, EN 61000-4-2, EN 61000-4-4, EN 61000-6-2, EN 61000-6-4, EN 60204 -1
  • ASME: Stamp R, Stamp S, Stamp U
  • Chinese standard: SELO
  • Swiss standard: SR 930.114
  • FDA
  • GMP

Would you like to know more about the Fedegari FOWS series? Contact us at 800-829-5741.

Making it simple but relevant, with Bonfiglioli Engineering Product Sheets

Don’t waste time wading through pages and pages of information to find the right package testing solution for you.

Introducing the Bonfiglioli Engineering Product Sheets, your one-stop resource for all the information you need to make the right decision.  

The B.E. product sheets give you a glimpse of the best possible solutions for your leak testing challenges through an overview of the highlights, indicating the machine “Unique Benefits”, following a tabular method for easy reading, containing only relevant information that helps you quickly identify the ideal solution and technology that perfectly fits your needs.

Making it simple but relevant, with Bonfiglioli Engineering Product Sheets. (this one!)

Check them out! You can find them on the Bonfiglioli Engineering website or you can contact your local agent or Area Sales Manager for information now.

ST-FT1 Chuck Calibrator

Mesa Labs’ new ST-FT1 is a universal handheld torque/force display that, when coupled with the Chuck calibrator adapter, can be used to verify/calibrate chuck capper heads. Cap adapters are easily replaceable to accommodate various chucks.

Possible causes of equipment related torque variation:

  • servo current fluctuation
  • temperature variation related torque fluctuation of a magnetic slip chuck
  • varying chuck speed
  • varying friction between the chuck and the cap OD (slippage)
  • topload force variation

To verify chuck-capper operation, use Mesa’s ST-FT1 chuck calibrator. This is a compact torque testing device for both engineering (FAT of capping equipment, troubleshooting torque issues of existing capping equipment) and production use (individual capper chuck adjustment). With this device, you can prove whether the torque variation is the result of servo current fluctuation (inconsistent application torque), product variation or another variable in the capping process (gripping pressure, topload, etc).

Target applications include but not limited to:

  • OEM/Packaging Engineer testing the performance/repeatability of the torque applied by capper chucks during machine design, factory acceptance testing/validation.
  • Packaging line operator verifying and adjusting capper chucks
  • Packaging Engineer evaluating whether torque variation is caused by the capping equipment or the package.

Contact Life Scientific, Inc today to discover more info regarding this very capable torque tester.

TRAINING AS A RESOURCE

Over the past few years, Fedegari has shown constant commitment to formation and growth, investing and offering opportunities to young people from Pavia’s area and beyond.

In fact, the company opens its doors to youngsters, proposing wide and different possibilities for formation and training, with the aim of reaching and offering the highest levels of quality and at the same time guaranteeing participants a preparation for both a possible future and inside the company and for a different working perspective in Pavia’s territory in general.

On this basis Fedegari participates and takes part in projects, collaborations and activities aimed at discovering new talents, in order to give them the opportunity to learn about a business context in practical life through the aforementioned formation and training programs.

Through participation in events such as the career day of the University of Pavia, which allow Fedegari to discover, learn and get in touch with new figures, it is possible to set in motion a continuous revolution in which young ones are the main protagonists.

Fedegari has always been very keen on young people and considers their education a fundamental resource for the territory its-self, especially in such a richly international context where it risks being lost.

During the annual Career Day of the University of Pavia, which falls in the month of May, Fedegari presents itself to the students of the various faculties of the University, who, if interested, have the opportunity to leave their CV and thus establish a possible contact with the company.

Also of great importance for the company is the “school-work alternation” project agreed with the Technical Institute G. Cardano of Pavia, with which Fedegari has signed a 3-year collaboration. Thanks to this cooperation, annually, eight students will follow a training course that will accompany them during their last school year. During their time in the company the students will follow two paths: one focused on the welding process and one concerning 3D design techniques.

The ultimate goal of this process is, in addition to the training of students, to insert them and make them understand the mechanisms of a working reality and to explain them how the learnt productive processes intertwine in a generic business context.

Since training is one of the pillars of Fedegari, the company is committed to give its employees the possibility of combining work and school life, allowing them to carry out Masters and to continue with university studies, thus allowing everyone to satisfy your desire for knowledge.

Headspace Gas Analysis: What’s on the Shelf?

Many injectable drugs are sealed into containers (typically glass vials or ampoules) after processing, in protective atmospheres to avoid contact with air that can damage quality & effectiveness. Nobody would like to open a yogurt jar and find fungus or buy medicine and find it has lost its effectiveness due to oxidation.

Here we are identifying two main impacts: Business Impact and GMP (Good Manufacturing Practice) Impact. In the first case, the company can lose business, in the second, it could cause serious illness to people. Different Container Closure Integrity Testing (CCIT) methods can be put in place to avoid the above: Vacuum Decay, Pressure Decay, Force Decay, Lid Deflection, Spark Test and last but not the least Headspace Gas Analysis (HGA).

Pharmaceutical Companies are required to protect their products not only with proper and safe enclosures, but they must also fill the space that surrounds the product (i.e. headspace), with some particular gases (e.g. Nitrogen, Carbon Dioxide) or simply maintain a high level of vacuum inside the enclosure, to avoid contact with oxygen or moisture.

At this point dear reader, I hope you have understood why it is so important to know what’s happening inside the headspace of your container. Headspace Gas Analysis plays an important role among the CCITs. Let’s add some more details.

Two different methods can be used to inspect headspace: destructive and non-destructive methods. In the destructive method, measurement of gas percentage present inside closed package requires the necessity to bring part of its internal atmosphere in contact with a proper sensor (e.g. chemical cell or zirconium oxide for oxygen) to be able to produce electricity proportionally to the gas concentration or use optical fluorescence technologies in case of oxygen detection. Both inspection methods result in package destruction.

Tunable Diode Laser Absorption Spectroscopy (TDLAS) is a non-destructive method, able to measure the concentration of a certain gas in closed container, with a sufficient headspace size to pass through with a laser beam with fairly good transparency to laser light: glass and plastic containers can be inspected as well if these conditions are satisfied. TDLAS is a technology based on laser absorption spectroscopy, wherein the wavelength diode laser is tuned over the absorption line of the gas under test (760 nm for Oxygen, 1854 nm for Moisture, 2000 nm for Carbon Dioxide) and the intensity of the transmitted radiation is measured.

More the gas molecules are present in the head space, less the energy will arrive at the photodiode used to convert light into an electrical signal. The transmitted intensity can be related to the gas concentration by the Beer-Lambert law. It is possible to obtain information related to the gas under test measuring Area and Width of the Absorption Curve.

However, these measurements are unitless, so a Calibration Procedure is necessary to correlate these values to Gas Concentration (%) or Total Pressure (mbarA).

Calibration Procedure is strictly related to the Standards concept. It is possible to apply techniques of modulation in high frequency to further improve the signal-to-noise ratio, ensuring the detection of small variations of signals in front of a wider operating range: WMS (Wavelength Modulation Spectroscopy) and FMS (Frequency Modulation Spectroscopy) are the most common types of modulation techniques. FMS has a higher modulation frequency (some MHz) than WMS (some KHz); a lower laser residual noise is its main advantage; however, the detectable minimum quantity of gas is less dependent on laser residual noise than Etalon Effect for instance.

Furthermore, working at such high frequencies has another drawback: we need to use analog electronic components instead of digital ones thereby renouncing great advantages coming from them.

Now that we have more knowledge of this technology, we could be interested to understand how to take advantage from a non-destructive method.

You can focus on the following comparisons between the standard destructive method and the non-destructive HGA method to draw your own conclusions:

• Standard Methods to measure gas concentration or pressure value are destructive.

The packages can’t be recovered even if we have a conforming test… HGA is a non-destructive measurement method; packages can be recovered after confirming tests.

More valuable the product, more the item is important;

• Standard Methods are slow; they can’t guarantee 100% check of the whole production… HGA is very fast and it can be placed into an in-line process to test 100% of the production.

It is more expensive, but the return of investment covers the overall expenses;

• Standard Methods of Leak Detection don’t find non-conforming packages due to process anomalies if they are properly sealed… HGA finds non-conforming packages even if they are properly sealed; it measures the gas partial pressure in the headspace.

It is important to remember however, that HGA is not a leak detector if the quarantine period is not part of the production process.

I hope you have found some interesting food for thought about these intriguing arguments.

Unit Dose Packaging Manufacturers

The development of single dose packaging has been a breakthrough for unit dose packaging manufacturers. Single dose packaging or unit dose packaging has a variety of applications that can be beneficial for multiple industries.

Hospitals, pharmaceutical companies, and patients have greater control over medication and, additionally, reducing waste. What are the incredible benefits of unit dose packaging and why is it such a revolutionary development in the contract packaging industry?

The following article will detail this and highlight why the unit dose delivery system may be perfect for your product. If you have any more questions about unit dose packaging or would like to speak with our available packaging options and contract filling services, please contact LF of America

About Unit Dose Packaging

The name unit dose packaging refers to the single premeasured unit of a medicine or substance that the packaging holds. By pre-measuring the dose, the possibility of human error is drastically reduced.

Additionally, it makes the application much easier and comfortable for the user. All the materials used by unit dose packaging manufacturers like LF of America are also made of an eco-friendly bioplastic. 

Clinical and hospital settings can benefit greatly from the innovative single dose packaging development. Patients and personnel can enjoy improved application accuracy in addition to exact dose delivery.

Barcodes are placed on each unit that can easily identify each individual dose. In the event that the package is damaged or tampered with in any way, patients and personnel can identify it immediately.

As mentioned above, unit dose packaging reduces waste and is made from fully renewable resources. Unit dose packaging also makes documentation convenient by providing simple electronic documentation capabilities. 

Manufacturers of unit dose packaging provide numerous benefits for patients by having medication pre-measured prior to application. Unit dose packaging is highly versatile and also provides numerous benefits for other industries.

Amongst other applications, single dose packaging can be found in OTC pharmaceutical products, veterinary care, diagnostics, and cosmetics. 

Additional Benefits of Single Dose Packaging

Many health products provide samples for customers to try. Single dose packaging’s size and ability to protect its content makes it perfect for samples. Diagnostic test kits in unit dose containers are able to completely eliminate the possibility of human error while simultaneously improving personnel convenience. 

More forward-thinking businesses have begun discussing how to incorporate this revolutionary development. The convenient size of unit dose packaging and protection can make handing out gel, perfume, lotion, and other samples easier than ever before. 

One of the most recent industries to begin contacting unit dose packaging manufacturers is the CBD industry. Whether its medication, cosmetics, or CBD packaging, single dose packaging provides benefits like no other packaging method before it.

If you are interested in incorporating unit dose packaging for your business, please contact us today. We will gladly assist you and answer any questions you may have. We will also be happy to provide free samples filled with your product. 

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